Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence

Mary Grey Maher, Eva Sapi, Bruce Turner, Andrew Gumbs, Peter L. Perrotta, Darryl Carter, Barry M. Kacinski, Bruce G. Haffty

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48 Scopus citations


The macrophage colony-stimulating factor receptor (CSF-1R), the product of the c-fms proto-oncogene, regulates normal proliferation and differentiation of macrophages and trophoblasts. Recent research found abnormal expression of CSF-1R in human carcinomas of the breast, endometrium, and ovary. Furthermore, activation of CSF-1R by its ligand has been shown to regulate invasiveness and anchorage-independent growth in breast carcinoma cells. To study the significance of CSF-1R expression in breast cancer, we designed a case-controlled immunohistochemical study. We chose 80 patients from a database of 1200 early stage I or II breast cancer patients treated with conservative surgery and radiation therapy. Expression of CSF-1R in the tumors of 40 patients who experienced an ipsilateral breast tumor recurrence (IBTR) as a primary site of relapse were compared with 40 patients who had not experienced an IBTR. The index and control patients were matched by age, clinical stage, nodal status, and follow-up. Paraffin-embedded sections were immunostained with anti-bodies directed toward CSF-1R. For the CSF-1R antibody, a total of 28 index cases (70%) demonstrated strong staining, whereas only 16 control cases (40%) demonstrated high immunoreactivity (P = 0.007). The CSF-1R antibody showed a positive correlation for local relapse, but no correlation was found between CSF-1R expression and distant metastasis. In summary, our findings provide evidence for the poor prognostic role of CSF-1R in IBTR.

Original languageEnglish (US)
Pages (from-to)1851-1856
Number of pages6
JournalClinical Cancer Research
Issue number8
StatePublished - Aug 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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