TY - JOUR
T1 - Prognostic factors in breast cancer
T2 - Current and new predictors of metastasis
AU - Hayes, Daniel F.
AU - Isaacs, Claudine
AU - Stearns, Vered
N1 - Funding Information:
Supported by Grant CI-3 of the Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation and a grant from The Fashion Footwear Association of New York (FFANY) “Shoes-On-Sale”/QVC Presents°R.
PY - 2001/10
Y1 - 2001/10
N2 - Decisions regarding the use of adjuvant therapy for breast cancer are strongly influenced by the risk of disease recurrence and death. These risks are now determined by examining the currently recognized breast cancer prognostic factors, including clinical stage, axillary nodal status, tumor size and grade, hormone receptor status, and presence of lymphovascular involvement. Newer factors are being evaluated in an attempt to more precisely define disease-related prognosis. This paper provides an overview of issues that need to be considered when analyzing studies of prognostic factors as well as a review of the currently recognized and the newer candidate prognostic factors.
AB - Decisions regarding the use of adjuvant therapy for breast cancer are strongly influenced by the risk of disease recurrence and death. These risks are now determined by examining the currently recognized breast cancer prognostic factors, including clinical stage, axillary nodal status, tumor size and grade, hormone receptor status, and presence of lymphovascular involvement. Newer factors are being evaluated in an attempt to more precisely define disease-related prognosis. This paper provides an overview of issues that need to be considered when analyzing studies of prognostic factors as well as a review of the currently recognized and the newer candidate prognostic factors.
KW - Adjuvant systemic therapy
KW - Breast cancer
KW - Prognostic factors
KW - Tumor marker utility grading system
UR - http://www.scopus.com/inward/record.url?scp=0035495969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035495969&partnerID=8YFLogxK
U2 - 10.1023/A:1014778713034
DO - 10.1023/A:1014778713034
M3 - Review article
C2 - 12013528
AN - SCOPUS:0035495969
SN - 1083-3021
VL - 6
SP - 375
EP - 392
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
IS - 4
ER -