Prognostic factors following enucleation of 1 1 1 uveal melanomas

Kate Coleman, Jan P.A. Baak, Paul Van Diest, Joan Mullaney, Michael Farrell, Maurice Fenton

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59 Scopus citations


Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p<0002), presence of epithelioid cells (p<0-03), and glaucoma (p<O0OO1). A combination of cell type, glaucoma, and LTD (p<00001) had strong and independent prognostic significance in multivanate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.

Original languageEnglish (US)
Pages (from-to)688-692
Number of pages5
JournalBritish Journal of Ophthalmology
Issue number11
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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