Abstract
Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2593-2597 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 139 |
| Issue number | 8 |
| State | Published - 1987 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology