Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes

D. S. Robbins, Y. Shirazi, B. E. Drysdale, A. Lieberman, H. S. Shin, M. L. Shin

Research output: Contribution to journalArticlepeer-review


Stimulation of rat astrocytes in vitro by calcium ionophore A23187 and/or lipopolysaccharide results in the generation of a cytotoxic factor that is functionally similar to the previously described macrophage-derived cytotoxic factor, tumor necrosis factor. Like the macrophage product, the astrocyte cytotoxic factor kills murine L 929 cell targets. In addition, it kills rat oligodendrocytes, the myelin-producing cells of the central nervous system. Human recombinant tumor necrosis factor also has cytotoxic activity directed against rat oligodendrocytes.

Original languageEnglish (US)
Pages (from-to)2593-2597
Number of pages5
JournalJournal of Immunology
Issue number8
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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