Procollagens as markers for the cell of origin of human bone tumors

Robert Stern, Joseph Wilczek, William P. Thorpe, Steven A. Rosenberg

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Cells derived from osteogenic sarcomas and from Ewing's sarcomas, two malignant bone tumors, were examined for the types of collagens they elaborated into the tissue culture media. Type I procollagen was the predominant species from all osteogenic sarcoma cell lines, a finding consistent with bone cell origin. The Ewing's sarcoma cells contained a prominent peak of type III procollagen and resembled the profile of vascular smooth muscle cells. Fibroblasts derived from skin biopsies taken from amputation specimens synthesized both type I and type III procollagens at the expected ratio of approximately 3: 1. The examination of matrix proteins may provide a general classification scheme for human sarcomas and permit distinction of one tumor from another, as well as from normal fibroblasts.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalCancer Research
Issue number2
StatePublished - Feb 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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