Cells derived from osteogenic sarcomas and from Ewing's sarcomas, two malignant bone tumors, were examined for the types of collagens they elaborated into the tissue culture media. Type I procollagen was the predominant species from all osteogenic sarcoma cell lines, a finding consistent with bone cell origin. The Ewing's sarcoma cells contained a prominent peak of type III procollagen and resembled the profile of vascular smooth muscle cells. Fibroblasts derived from skin biopsies taken from amputation specimens synthesized both type I and type III procollagens at the expected ratio of approximately 3: 1. The examination of matrix proteins may provide a general classification scheme for human sarcomas and permit distinction of one tumor from another, as well as from normal fibroblasts.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Feb 1 1980|
ASJC Scopus subject areas
- Cancer Research