Procarcinogenic regulatory T cells in microbial-induced colon cancer

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

Original languageEnglish (US)
Issue number4
StatePublished - Apr 2 2016


  • Carcinogenesis
  • Enterotoxigenic Bacteroides fragilis
  • IL-17
  • Inflammation
  • Microbiome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology


Dive into the research topics of 'Procarcinogenic regulatory T cells in microbial-induced colon cancer'. Together they form a unique fingerprint.

Cite this