Probability of response models and DNA repair: a statistical-biological approach

Bruce Thompson; Charles A. Rohde

doi:10.1016/0025-5564(87)90088-5

Probability of response models and DNA repair: a statistical-biological approach

Bruce Thompson, Charles A. Rohde

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This paper develops a simple statistical model, the weighted hazard model, which incorporates the toxicological idea of DNA repair and its role in chemical carcinogenesis. We restrict attention to a small segment of DNA that migrates in and out of the high risk states; it is shown that random hazard functions play an important role in the distributional properties of the time to first detectable tumor. Included in the many shapes of the weighted hazard model is one that has a shape in the low dose region similar to that of the probit model, a model that many toxicologists favor. The analyses of two data sets are presented and interpreted, and suggestions for further research are given.

Original language	English (US)
Pages (from-to)	139-153
Number of pages	15
Journal	Mathematical Biosciences
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/0025-5564(87)90088-5
State	Published - Jun 1987

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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abstract = "This paper develops a simple statistical model, the weighted hazard model, which incorporates the toxicological idea of DNA repair and its role in chemical carcinogenesis. We restrict attention to a small segment of DNA that migrates in and out of the high risk states; it is shown that random hazard functions play an important role in the distributional properties of the time to first detectable tumor. Included in the many shapes of the weighted hazard model is one that has a shape in the low dose region similar to that of the probit model, a model that many toxicologists favor. The analyses of two data sets are presented and interpreted, and suggestions for further research are given.",

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AB - This paper develops a simple statistical model, the weighted hazard model, which incorporates the toxicological idea of DNA repair and its role in chemical carcinogenesis. We restrict attention to a small segment of DNA that migrates in and out of the high risk states; it is shown that random hazard functions play an important role in the distributional properties of the time to first detectable tumor. Included in the many shapes of the weighted hazard model is one that has a shape in the low dose region similar to that of the probit model, a model that many toxicologists favor. The analyses of two data sets are presented and interpreted, and suggestions for further research are given.

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Probability of response models and DNA repair: a statistical-biological approach

Abstract

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