TY - GEN
T1 - Printing mechanically tunable cardiac decellularized extracellular matrix bioinks for modeling cardiac fibrosis
AU - Shin, Yu Jung
AU - Shafranek, Ryan
AU - Tsui, Jonathan
AU - Nelson, Alshakim
AU - Kim, Deok Ho
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Cardiac fibrosis is a devastating form of pathological remodeling in the myocardium, which results in progressive heart failure. Therefore, there is need for an in vitro platform that mimics the structural and mechanical properties of in vivo conditions to study disease mechanisms. We hypothesize that 3D-printed, cell-laden constructs derived from the cardiac ECM can be used to recapitulate the in vivo properties of both healthy and fibrotic cardiac tissues. In this work, we report bioinks composed of decellularized ECM (dECM), Laponite, and poly(ethylene glycol)-diacrylate (PEG-DA) that are extrudable, photo-crosslinkable, and demonstrate good printing fidelity. Furthermore, the shear storage modulus (G’) after photocuring can be tuned to model the stiffness of both healthy and fibrotic cardiac tissue.
AB - Statement of Purpose: Cardiac fibrosis is a devastating form of pathological remodeling in the myocardium, which results in progressive heart failure. Therefore, there is need for an in vitro platform that mimics the structural and mechanical properties of in vivo conditions to study disease mechanisms. We hypothesize that 3D-printed, cell-laden constructs derived from the cardiac ECM can be used to recapitulate the in vivo properties of both healthy and fibrotic cardiac tissues. In this work, we report bioinks composed of decellularized ECM (dECM), Laponite, and poly(ethylene glycol)-diacrylate (PEG-DA) that are extrudable, photo-crosslinkable, and demonstrate good printing fidelity. Furthermore, the shear storage modulus (G’) after photocuring can be tuned to model the stiffness of both healthy and fibrotic cardiac tissue.
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M3 - Conference contribution
AN - SCOPUS:85065422024
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 903
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -