Primus inter pares (First among equals)

J. L. Keck; J. M. Berger

doi:10.1038/82996

Primus inter pares (First among equals)

J. L. Keck
, J. M. Berger

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Nature Structural Biology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/82996
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Biochemistry
Genetics

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10.1038/82996

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title = "Primus inter pares (First among equals)",

abstract = "Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.",

author = "Keck, \{J. L.\} and Berger, \{J. M.\}",

year = "2001",

doi = "10.1038/82996",

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journal = "Nature Structural Biology",

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AU - Keck, J. L.

AU - Berger, J. M.

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N2 - Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.

AB - Priming of DNA replication in eukaryotes is carried out by a heterotetrameric complex known as pol α-primase. The structure of the Pyrococcus furiosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insights into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three domains of life.

UR - https://www.scopus.com/pages/publications/0035164892

UR - https://www.scopus.com/pages/publications/0035164892#tab=citedBy

U2 - 10.1038/82996

DO - 10.1038/82996

M3 - Short survey

C2 - 11135655

AN - SCOPUS:0035164892

SN - 1072-8368

VL - 8

SP - 2

EP - 4

JO - Nature Structural Biology

JF - Nature Structural Biology

IS - 1

ER -

Primus inter pares (First among equals)

Abstract

ASJC Scopus subject areas

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