Primary structure and properties of the Na+/glucose symporter (SglS) of Vibrio parahaemolyticus

Rafiquel I. Sarker, Wakano Ogawa, Toshi Shimamoto, Tadashi Shimamoto, Tomofusa Tsuchiya

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Previously, we cloned and sequenced a DNA fragment from Vibrio parahaemolyticus and found four open rending frames (ORFs). Here, we clearly demonstrate that one of the ORFs, ORF1, is the gene (sglS) encoding a Na+/glucose symporter (SglS). We characterize the Na+/glucose symporter produced in Escherichia mutant (JM1100) cells which lack original glucose transport activity and galactose transport activity. We also show that phlorizin, a potent inhibitor of the SGLT1 Na+/glucose symporter of animal cells, inhibited glucose transport, but not galactose transport, via the SglS system.

Original languageEnglish (US)
Pages (from-to)1805-1808
Number of pages4
JournalJournal of bacteriology
Issue number5
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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