Primary pulmonary hypertension and cirrhosis: Are they related?

P. J. McDonnell, P. A. Toye, G. M. Hutchins

Research output: Contribution to journalArticlepeer-review

261 Scopus citations


The relationship of primary pulmonary hypertension to longstanding portal hypertension secondary to hepatic cirrhosis ws examined. An unselected series of 17,901 autopsied patients older than 1 yr of age showed that primary pulmonary hypertension occurred with a prevalence of 0.13% in all patients, but with a prevalence of 0.73% among patients with cirrhosis (p < 0.001). A clinical series of 2,459 patients with biopsy-proved hepatic cirrhosis showed a prevalence of primary pulmonary hypertension of 0.61%, also significant (p < 0.001) when compared with the prevalence among all patients older than 1 yr of age at autopsy. These data appear to exclude a coincidental association of cirrhosis with the development of the vascular lesions of primary pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)437-441
Number of pages5
JournalAmerican Review of Respiratory Disease
Issue number4
StatePublished - 1983

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Primary pulmonary hypertension and cirrhosis: Are they related?'. Together they form a unique fingerprint.

Cite this