Primary pulmonary arterial hypertension presenting as diffuse micronodules on CT

Maureen R. Horton, R. M. Tuder

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Primary pulmonary arterial hypertension is a rare lethal disease that typically presents radiographically with enlarged central pulmonary arteries, pruning of the peripheral vasculature, and cardiomegaly but clear lung fields. Although it is a disease of unknown etiology, primary PAH has been associated with anorexigen use. We present a case of pulmonary arterial hypertension in a woman with a history of fenfluramine and phentermine use who presented with diffuse micronodules on computed tomography scan. Lung biopsy confirmed the micronodules were radiographic manifestations of extensive diffuse plexogenic arterial lesions. This report represents an unusual radiographic presentation of anorexigen related pulmonary arterial hypertension, and to our knowledge, the first case reported as presenting with diffuse micronodules on high resolution computed tomography scan.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalCritical reviews in computed tomography
Issue number5-6
StatePublished - 2004
Externally publishedYes


  • Anorexigen
  • CT
  • Micronodules
  • Pulmonary arterial hypertension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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