Primary leiomyosarcoma of the kidney: A clinicopathologic study of 27 cases

Jeremy S. Miller, Ming Zhou, Fadi Brimo, Charles C. Guo, Jonathan I. Epstein

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Primary leiomyosarcoma of the kidney is a rare entity that has not been well characterized. We retrieved 27 cases of primary renal leiomyosarcomas diagnosed at 3 institutions between 1986 and 2009. Mean patient age at diagnosis was 58.5 years (range 22 to 85), and 59% were female. Mean tumor size was 13.4 cm (range 4 to 26), and 59% of the tumors were identified in the right kidney. Detailed histologic examination was possible for 24 of the cases. Average mitotic count per 10 high-power fields was 11.1 (range 0 to 50), and the average extent of necrosis was 21% (range 0 to 60). Cellular pleomorphism was classified as either focal (n=13) or extensive (n=11) and graded as mild (n=3), moderate (n=7) or severe (n=14). Tumors were either grade 2 (n=12) or grade 3 (n=12) using the French Federation of Cancer Centers System. Direct extension beyond the kidney capsule was identified in 55% of the cases, and lymphovascular invasion was identified in 26%. Clinical follow-up information was available for 20 of the cases, and patients were followed for an average of 2.8 years (range 0.25 to 9). Distant metastases were identified in 90% of the patients, and 75% eventually died from their tumor's burden. In conclusion, primary renal leiomyosarcomas have a grim prognosis regardless of the underlying histology.

Original languageEnglish (US)
Pages (from-to)238-242
Number of pages5
JournalAmerican Journal of Surgical Pathology
Issue number2
StatePublished - Feb 2010


  • Kidney
  • Leiomyosarcoma
  • Sarcoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine


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