Primary anaplastic large cell lymphoma of the lung: A clinicopathologic study of five patients

Walter L. Rush, Jo Ann W. Andriko, Jeffrey K. Taubenberger, Ann M. Nelson, Susan L. Abbondanzo, William D. Travis, Michael N. Koss

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Primary anaplastic large-cell lymphoma is a rare malignancy in the lung. Anaplastic large-cell lymphoma characteristically involves the lymph nodes or skin, with few reports from other sites. We studied the clinical and pathologic features of five cases of anaplastic large-cell lymphoma limited to the lungs. The patients were three women and two men aged 27 to 66 years (mean, 44.6 y). The tumors ranged in size from 1.1 to 5 cm. All patients were CD 30 (Ki-1) positive and CD 15 (LeuM-1) negative. Epithelial membrane antigen immunoreactivity was seen in two patients. Epstein-Barr virus was not detected by immunohistochemistry (four patients tested) or by polymerase chain reaction studies (three patients tested). The immunophenotypes were T cell (n = 3) and null (n = 2). Gene rearrangement studies supported the immunophenotypic findings. One patient who had underlying HIV infection died of infectious complications. One patient died at 6 months. Two patients developed recurrent disease and are alive after 42 and 51 months of follow-up. The remaining patient is alive at 8 years of follow-up without evidence of disease. ALCL can mimic metastatic or primary carcinoma and should be considered in the differential diagnosis of large cell neoplasms of the lung.

Original languageEnglish (US)
Pages (from-to)1285-1292
Number of pages8
JournalModern Pathology
Issue number12
StatePublished - 2000
Externally publishedYes


  • Anaplastic large cell lymphoma
  • Epstein-Barr virus
  • Human Immunodeficiency Virus
  • Lung

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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