Primary acquired melanosis with atypia treated with mitomycin C

Wendy V. Anandajeya; Zélia M. Corrêa; James J. Augsburger

doi:10.1007/s10792-008-9225-3

Primary acquired melanosis with atypia treated with mitomycin C

Wendy V. Anandajeya, Zélia M. Corrêa, James J. Augsburger

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The authors report the case of a 56-year-old Caucasian man who was found to have prominent melanotic conjuntival pigmentation inferotemporally in his right eye. Histopathologic evaluation disclosed malignant melanoma of the conjunctiva arising within primary acquired melanosis (PAM) associated with melanocytic atypia. The patient was treated by incisional conjunctival biopsy followed by two cycles of mitomycin C 0.04% eye drops and supplemental double-freeze thaw cryotherapy to residual foci of PAM. By 1 year following this treatment, there was no clinically apparent residual conjunctival melanosis, and visual acuity remained stable at 20/30.

Original language	English (US)
Pages (from-to)	285-288
Number of pages	4
Journal	International Ophthalmology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1007/s10792-008-9225-3
State	Published - 2009
Externally published	Yes

Keywords

Mitomycin C
Primary acquired melanosis

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1007/s10792-008-9225-3

Cite this

@article{4d411a9555ec4082827aabac5fff5d1f,

title = "Primary acquired melanosis with atypia treated with mitomycin C",

abstract = "The authors report the case of a 56-year-old Caucasian man who was found to have prominent melanotic conjuntival pigmentation inferotemporally in his right eye. Histopathologic evaluation disclosed malignant melanoma of the conjunctiva arising within primary acquired melanosis (PAM) associated with melanocytic atypia. The patient was treated by incisional conjunctival biopsy followed by two cycles of mitomycin C 0.04% eye drops and supplemental double-freeze thaw cryotherapy to residual foci of PAM. By 1 year following this treatment, there was no clinically apparent residual conjunctival melanosis, and visual acuity remained stable at 20/30.",

keywords = "Mitomycin C, Primary acquired melanosis",

author = "Anandajeya, {Wendy V.} and Corr{\^e}a, {Z{\'e}lia M.} and Augsburger, {James J.}",

note = "Funding Information: Acknowledgements Financial support This work was supported in part by an Unrestricted Grant from Research to Prevent Blindness, Inc., New York, NY, to the University of Cincinnati{\textquoteright}s Department of Ophthalmology (James J. Augsburger, MD, Chairman).",

year = "2009",

doi = "10.1007/s10792-008-9225-3",

language = "English (US)",

volume = "29",

pages = "285--288",

journal = "International Ophthalmology",

issn = "0165-5701",

publisher = "Springer Netherlands",

number = "4",

}

TY - JOUR

T1 - Primary acquired melanosis with atypia treated with mitomycin C

AU - Anandajeya, Wendy V.

AU - Corrêa, Zélia M.

AU - Augsburger, James J.

N1 - Funding Information: Acknowledgements Financial support This work was supported in part by an Unrestricted Grant from Research to Prevent Blindness, Inc., New York, NY, to the University of Cincinnati’s Department of Ophthalmology (James J. Augsburger, MD, Chairman).

PY - 2009

Y1 - 2009

N2 - The authors report the case of a 56-year-old Caucasian man who was found to have prominent melanotic conjuntival pigmentation inferotemporally in his right eye. Histopathologic evaluation disclosed malignant melanoma of the conjunctiva arising within primary acquired melanosis (PAM) associated with melanocytic atypia. The patient was treated by incisional conjunctival biopsy followed by two cycles of mitomycin C 0.04% eye drops and supplemental double-freeze thaw cryotherapy to residual foci of PAM. By 1 year following this treatment, there was no clinically apparent residual conjunctival melanosis, and visual acuity remained stable at 20/30.

AB - The authors report the case of a 56-year-old Caucasian man who was found to have prominent melanotic conjuntival pigmentation inferotemporally in his right eye. Histopathologic evaluation disclosed malignant melanoma of the conjunctiva arising within primary acquired melanosis (PAM) associated with melanocytic atypia. The patient was treated by incisional conjunctival biopsy followed by two cycles of mitomycin C 0.04% eye drops and supplemental double-freeze thaw cryotherapy to residual foci of PAM. By 1 year following this treatment, there was no clinically apparent residual conjunctival melanosis, and visual acuity remained stable at 20/30.

KW - Mitomycin C

KW - Primary acquired melanosis

UR - http://www.scopus.com/inward/record.url?scp=68249148093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68249148093&partnerID=8YFLogxK

U2 - 10.1007/s10792-008-9225-3

DO - 10.1007/s10792-008-9225-3

M3 - Article

C2 - 18438612

AN - SCOPUS:68249148093

SN - 0165-5701

VL - 29

SP - 285

EP - 288

JO - International Ophthalmology

JF - International Ophthalmology

IS - 4

ER -

Primary acquired melanosis with atypia treated with mitomycin C

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this