Preventive Treatment for Household Contacts of Drug-Susceptible Tuberculosis Patients

Nicole Salazar-Austin; Christiaan Mulder; Graeme Hoddinott; Theresa Ryckman; Colleen F. Hanrahan; Kavindhran Velen; Lucy Chimoyi; Salome Charalambous; Violet N. Chihota

doi:10.3390/pathogens11111258

Preventive Treatment for Household Contacts of Drug-Susceptible Tuberculosis Patients

Nicole Salazar-Austin, Christiaan Mulder, Graeme Hoddinott, Theresa Ryckman, Colleen F. Hanrahan, Kavindhran Velen, Lucy Chimoyi, Salome Charalambous, Violet N. Chihota

Research output: Contribution to journal › Review article › peer-review

Abstract

People who live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The treatment of TB infection is critical to prevent the progression of infection to disease and is prioritized in household contacts. Despite the availability of TPT, uptake in household contacts is poor. Multiple barriers prevent the optimal implementation of these policies. This manuscript lays out potential next steps for closing the policy-to-implementation gap in household contacts of all ages.

Original language	English (US)
Article number	1258
Journal	Pathogens
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/pathogens11111258
State	Published - Nov 2022

Keywords

TB infection
TB preventive treatment
household contacts

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
General Immunology and Microbiology
Molecular Biology
Immunology and Allergy

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10.3390/pathogens11111258

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title = "Preventive Treatment for Household Contacts of Drug-Susceptible Tuberculosis Patients",

abstract = "People who live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The treatment of TB infection is critical to prevent the progression of infection to disease and is prioritized in household contacts. Despite the availability of TPT, uptake in household contacts is poor. Multiple barriers prevent the optimal implementation of these policies. This manuscript lays out potential next steps for closing the policy-to-implementation gap in household contacts of all ages.",

keywords = "TB infection, TB preventive treatment, household contacts",

author = "Nicole Salazar-Austin and Christiaan Mulder and Graeme Hoddinott and Theresa Ryckman and Hanrahan, {Colleen F.} and Kavindhran Velen and Lucy Chimoyi and Salome Charalambous and Chihota, {Violet N.}",

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AU - Salazar-Austin, Nicole

AU - Mulder, Christiaan

AU - Hoddinott, Graeme

AU - Ryckman, Theresa

AU - Hanrahan, Colleen F.

AU - Velen, Kavindhran

AU - Chimoyi, Lucy

AU - Charalambous, Salome

AU - Chihota, Violet N.

PY - 2022/11

Y1 - 2022/11

N2 - People who live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The treatment of TB infection is critical to prevent the progression of infection to disease and is prioritized in household contacts. Despite the availability of TPT, uptake in household contacts is poor. Multiple barriers prevent the optimal implementation of these policies. This manuscript lays out potential next steps for closing the policy-to-implementation gap in household contacts of all ages.

AB - People who live in the household of someone with infectious pulmonary tuberculosis are at a high risk of tuberculosis infection and subsequent progression to tuberculosis disease. These individuals are prioritized for contact investigation and tuberculosis preventive treatment (TPT). The treatment of TB infection is critical to prevent the progression of infection to disease and is prioritized in household contacts. Despite the availability of TPT, uptake in household contacts is poor. Multiple barriers prevent the optimal implementation of these policies. This manuscript lays out potential next steps for closing the policy-to-implementation gap in household contacts of all ages.

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KW - TB preventive treatment

KW - household contacts

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JO - Pathogens

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Preventive Treatment for Household Contacts of Drug-Susceptible Tuberculosis Patients

Abstract

Keywords

ASJC Scopus subject areas

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