Prevention and treatment of pneumocystis carinii pneumonia

Walter T. Hughes

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Several drugs are now available for the treatment and prevention of Pneumocystis carinii pneumonia. These include trimethoprim-sulfamethoxazole and pentamidine isethionate as first-line drugs and dapsone-trimethoprim, trimetrexate, piritrexim, fansidar, difluoromethylornithine, and clindamycin plus primaquine as drugs in later stages of clinical development. A hydroxynaphthoquinone, called 566C80, offers promise in preclinical studies. The use of corticosteroids in the supportive management of P. carinii pneumonitis is undergoing clinical study.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalAnnual review of medicine
StatePublished - 1991
Externally publishedYes


  • Immunocompromised host
  • Pentamidine
  • Trimethoprim-sulfamethoxazole

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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