Prevention and management of Ovarian Hyperstimulation Syndrome

Nikos F. Vlahos, Odysseas Gregoriou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

51 Scopus citations


The Ovarian Hyperstimulation Syndrome (OHSS) represents one of the biggest nightmares of all physicians involved in Assisted Reproductive Technologies (ART). Every year, several hundreds of women are hospitalized and to date several deaths have been reported. The pivotal event in the development of OHSS is the disruption of capillary integrity that results in leakage of intravascular fluid and proteins into third space. On the molecular level, human chorionic godadotropin (HCG) either exogenous or endogenous, functions as the triggering point for the production of vascular endothelial growth factor (VEGF) that is the main mediator to increase permeability on the vascular bed. Spontaneous OHSS has also been reported, either due to inappropriate activation of a mutant FSH receptor or due to very high levels of HCG during pregnancy. The available evidence on the several preventive and therapeutic approaches with special attention to level 1 evidence when available is also presented. OHSS is a self-resolving condition and the main role of the physician is to correct and maintain the intravascular volume, to support renal function and respiration and prevent thrombotic events. An algorithm on the management of OHSS on an outpatient basis and in the hospital is based on the previous mentioned principles.

Original languageEnglish (US)
Title of host publicationWomen's Health and Disease
Subtitle of host publicationGynecologic, Endocrine, and Reproductive Issues
PublisherBlackwell Publishing Inc.
Number of pages18
ISBN (Print)1573316210, 9781573316217
StatePublished - Dec 2006
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Gonadotropins
  • Oocytes, pregnancy
  • Ovarian hyperstimulation syndrome (OHSS)

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


Dive into the research topics of 'Prevention and management of Ovarian Hyperstimulation Syndrome'. Together they form a unique fingerprint.

Cite this