Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists

Maximilian F. Konig; Mike Powell; Verena Staedtke; Ren Yuan Bai; David L. Thomas; Nicole Fischer; Sakibul Huq; Adham M. Khalafallah; Allison Koenecke; Ruoxuan Xiong; Brett Mensh; Nickolas Papadopoulos; Kenneth W. Kinzler; Bert Vogelstein; Joshua T. Vogelstein; Susan Athey; Shibin Zhou; Chetan Bettegowda

doi:10.1172/JCI139642

Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists

Maximilian F. Konig, Mike Powell, Verena Staedtke, Ren Yuan Bai, David L. Thomas, Nicole Fischer, Sakibul Huq, Adham M. Khalafallah, Allison Koenecke, Ruoxuan Xiong, Brett Mensh, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Joshua T. Vogelstein, Susan Athey, Shibin Zhou, Chetan Bettegowda

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Dysregulated host immune responses drive mortality in pneumonia and acute respiratory distress syndrome (ARDS) caused by a wide range of infections. In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits an exuberant local or systemic immune response (hyperinflammation) in the lung and other sites of viral replication, compromising organ function and leading to high morbidity and mortality (1-4).

Original language	English (US)
Pages (from-to)	3345-3347
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	130
Issue number	7
DOIs	https://doi.org/10.1172/JCI139642
State	Published - Jul 1 2020

ASJC Scopus subject areas

General Medicine

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Konig, M. F., Powell, M., Staedtke, V., Bai, R. Y., Thomas, D. L., Fischer, N., Huq, S., Khalafallah, A. M., Koenecke, A., Xiong, R., Mensh, B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Vogelstein, J. T., Athey, S., Zhou, S., & Bettegowda, C. (2020). Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists. Journal of Clinical Investigation, 130(7), 3345-3347. https://doi.org/10.1172/JCI139642

Konig, MF, Powell, M, Staedtke, V , Bai, RY , Thomas, DL, Fischer, N, Huq, S, Khalafallah, AM, Koenecke, A, Xiong, R, Mensh, B, Papadopoulos, N , Kinzler, KW , Vogelstein, B , Vogelstein, JT, Athey, S, Zhou, S & Bettegowda, C 2020, 'Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists', Journal of Clinical Investigation, vol. 130, no. 7, pp. 3345-3347. https://doi.org/10.1172/JCI139642

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abstract = "Dysregulated host immune responses drive mortality in pneumonia and acute respiratory distress syndrome (ARDS) caused by a wide range of infections. In coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits an exuberant local or systemic immune response (hyperinflammation) in the lung and other sites of viral replication, compromising organ function and leading to high morbidity and mortality (1-4).",

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AU - Staedtke, Verena

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AU - Thomas, David L.

AU - Fischer, Nicole

AU - Huq, Sakibul

AU - Khalafallah, Adham M.

AU - Koenecke, Allison

AU - Xiong, Ruoxuan

AU - Mensh, Brett

AU - Papadopoulos, Nickolas

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Vogelstein, Joshua T.

AU - Athey, Susan

AU - Zhou, Shibin

AU - Bettegowda, Chetan

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Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists

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