Preventing Cardiovascular Disease in Patients with Diabetes: Use of Aspirin for Primary Prevention

Dhaval Desai, Haitham M. Ahmed, Erin D. Michos

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Diabetics are at high risk for atherosclerotic cardiovascular disease (ASCVD) and are considered a coronary heart disease risk equivalent. The utility of aspirin in primary prevention of ASCVD in diabetic patients has been widely studied and is still debated. Overall, the current evidence suggests a modest benefit for reduction in ASCVD events with the greatest benefit among those with higher baseline risk, but at the cost of increased risk of gastrointestinal bleeding. Diabetic patients at higher risk (with 10-year ASCVD risk >10 %) are generally recommended for aspirin therapy if bleeding risk is felt to be low. A patient-provider discussion is recommended before prescribing aspirin therapy. Novel markers such as coronary artery calcium scores and high-sensitivity C-reactive protein may help refine ASCVD risk prediction and guide utility for aspirin therapy. This article will review the literature for the most up-to-date studies evaluating aspirin therapy for primary prevention of ASCVD in patients with diabetes.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalCurrent Cardiology Reports
Issue number3
StatePublished - Mar 2015


  • Aspirin
  • Cardiovascular disease
  • Diabetes
  • Primary prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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