TY - JOUR
T1 - Prevalence of high HbA1c levels in Brazilian adolescents
T2 - The Study of Cardiovascular Risk in Adolescents
AU - de Cássia Lima Fernandes, Rita
AU - Teló, Gabriela H.
AU - Cureau, Felipe V.
AU - Barufaldi, Laura A.
AU - Kuschnir, Maria Cristina C.
AU - Schaan, Beatriz D.
AU - Szklo, Moyses
AU - Bloch, Katia V.
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Aim To evaluate the prevalence of elevated glycated haemoglobin (HbA1c) levels in a population of adolescents participating in the Study of Cardiovascular Risk in Adolescents. Methods This is a school-based cross-sectional study based on a complex sample of adolescents 12–17 years old representative at the national and macro-regional levels and for each Brazilian state capital. Blood was collected in schools and then evaluated in a single laboratory. HbA1c levels were considered elevated if ⩾5.7% (39 mmol/mol) and were analyzed according to sex, age, macro-region, type of school, skin color, and nutritional status. Results Data from 37,804 adolescents were analyzed. The mean level of HbA1c was 5.4% (95%CI 5.4–5.4) (36 mmol/mol [95%CI 36–36]), and 20.5% (95%CI 19.1–22.0) of adolescents presented values ⩾5.7% (⩾39 mmol/mol). Among males, 23.6% (95%CI 21.8–25.6) showed elevated HbA1c levels compared to 17.5% (95%CI 15.9–19.2) observed in females. The prevalence of elevated levels of HbA1c was higher in adolescents with black skin color (27.6%; 95%CI 23.2–32.4) vs. white skin color (16.9%; 95%CI 15.4–18.5), and higher in those who studied in public schools (21.6%; 95%CI 20.0–23.4) vs. private schools (16.7%; 95%CI 14.7–19.0). Among obese adolescents, 29.7% (95%CI 25.4–34.3) had elevated levels of HbA1c, compared to 19.3% (95%CI 18.0–20.7) in normal weight students and 19.7% (95%CI 17.1–22.6) in overweight adolescents. Conclusions Obese male adolescents of lower socioeconomic status had a higher prevalence of elevated HbA1c levels. Our findings highlight the importance of focusing on this high risk group for interventions to prevent diabetes.
AB - Aim To evaluate the prevalence of elevated glycated haemoglobin (HbA1c) levels in a population of adolescents participating in the Study of Cardiovascular Risk in Adolescents. Methods This is a school-based cross-sectional study based on a complex sample of adolescents 12–17 years old representative at the national and macro-regional levels and for each Brazilian state capital. Blood was collected in schools and then evaluated in a single laboratory. HbA1c levels were considered elevated if ⩾5.7% (39 mmol/mol) and were analyzed according to sex, age, macro-region, type of school, skin color, and nutritional status. Results Data from 37,804 adolescents were analyzed. The mean level of HbA1c was 5.4% (95%CI 5.4–5.4) (36 mmol/mol [95%CI 36–36]), and 20.5% (95%CI 19.1–22.0) of adolescents presented values ⩾5.7% (⩾39 mmol/mol). Among males, 23.6% (95%CI 21.8–25.6) showed elevated HbA1c levels compared to 17.5% (95%CI 15.9–19.2) observed in females. The prevalence of elevated levels of HbA1c was higher in adolescents with black skin color (27.6%; 95%CI 23.2–32.4) vs. white skin color (16.9%; 95%CI 15.4–18.5), and higher in those who studied in public schools (21.6%; 95%CI 20.0–23.4) vs. private schools (16.7%; 95%CI 14.7–19.0). Among obese adolescents, 29.7% (95%CI 25.4–34.3) had elevated levels of HbA1c, compared to 19.3% (95%CI 18.0–20.7) in normal weight students and 19.7% (95%CI 17.1–22.6) in overweight adolescents. Conclusions Obese male adolescents of lower socioeconomic status had a higher prevalence of elevated HbA1c levels. Our findings highlight the importance of focusing on this high risk group for interventions to prevent diabetes.
KW - Adolescent
KW - Developing countries
KW - Diabetes mellitus
KW - Hemoglobin A, glycosylated
KW - Obesity
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U2 - 10.1016/j.diabres.2017.01.003
DO - 10.1016/j.diabres.2017.01.003
M3 - Article
C2 - 28129564
AN - SCOPUS:85010223674
SN - 0168-8227
VL - 125
SP - 1
EP - 9
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
ER -