TY - JOUR
T1 - Prevalence of hepatitis B surface antigen and serological markers of other endemic infections in HIV-infected children, adolescents and pregnant women in Sierra Leone
T2 - A cross-sectional study
AU - Yendewa, George A.
AU - Lakoh, Sulaiman
AU - Yendewa, Sahr A.
AU - Bangura, Khadijah
AU - Lawrence, Hannah
AU - Patiño, Lucia
AU - Jiba, Darlinda F.
AU - Vandy, Alren O.
AU - Murray, Mariama J.S.
AU - Massaquoi, Samuel P.
AU - Deen, Gibrilla F.
AU - Sahr, Foday
AU - Hoffmann, Christopher J.
AU - Jacobson, Jeffrey M.
AU - Poveda, Eva
AU - Aguilera, Antonio
AU - Salata, Robert A.
N1 - Funding Information:
GAY was supported by the Roe Green Travel Medicine and Global Health Award 2019, University Hospitals Cleveland Medical Center (Award Number J0628) .
Funding Information:
GAY was supported by the Roe Green Travel Medicine and Global Health Award 2019, University Hospitals Cleveland Medical Center (Award NumberJ0628).EP was supported by Plan Estatal de I+D+I 2013?2016 and 2017?2020 and co-financed by Instituto de Salud Carlos III (ISCIII)-Subdirecci?n General de Evaluaci?n y Fomento de la investigaci?n del Fondo Europeo de Desarrollo Regional (FEDER)PI16/02159,BA18/00034,PI19/00747,RETICS,Red de Investigaci?n en SIDA (RD16/0025/0026) andFundaci?n Biom?dica Galicia Sur?.
Funding Information:
EP was supported by Plan Estatal de I+D+I 2013–2016 and 2017–2020 and co-financed by I nstituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación y Fomento de la investigación del Fondo Europeo de Desarrollo Regional (FEDER) PI16/02159, BA18/00034, PI19/00747, RETICS, Red de Investigación en SIDA ( RD16/0025/0026) and Fundación Biomédica Galicia Sur .
Publisher Copyright:
© 2020 The Author(s)
PY - 2021/1
Y1 - 2021/1
N2 - Objective: To assess the prevalence of serological markers of HBV and endemic acute and chronic infections (HAV, HCV, CMV, HTLV-1/2 and syphilis) in HIV-infected children, adolescents and pregnant women in Sierra Leone. Method: We conducted a cross-sectional study at the national children's and women's hospitals in Freetown. Logistic regression was used to assess predictors of HBsAg positivity. Results: 183 HIV-infected participants were enrolled, comprising children (n = 88), adolescents (n = 47) and pregnant women (n = 48). All participants (100%) were CMV IgG-positive, while 56.8%, 93.6% and 100% of children, adolescents and pregnant women, respectively, were HAV IgG-positive. The prevalence of HCV, HTLV-1/2 and syphilis were <4%. HBV markers were distributed as follows—children: HBsAg (2.3%), HBeAg (0%), anti-HBc (5.7%); adolescents: HBsAg (17.0%), HBeAg (6.4%), anti-HBc (27.7%); and pregnant women: HBsAg (18.8%), HBeAg (4.2%), anti-HBc (77.1%). Age >10 years, i.e., being born pre-2009 before implementation of routine hepatitis B immunization (aOR 5.05 [1.18−21.28]; p = 0.029) and CD4 count <350 cells/mm3 (aOR 3.97 [1.07−14.71]; p = 0.039) predicted HBsAg positivity. Conclusion: A high burden of chronic HBV and other endemic infections was observed among HIV-infected patients born pre-2009 before implementation of routine HBV immunization in Sierra Leone, warranting targeted screening and immunization of this high-risk population.
AB - Objective: To assess the prevalence of serological markers of HBV and endemic acute and chronic infections (HAV, HCV, CMV, HTLV-1/2 and syphilis) in HIV-infected children, adolescents and pregnant women in Sierra Leone. Method: We conducted a cross-sectional study at the national children's and women's hospitals in Freetown. Logistic regression was used to assess predictors of HBsAg positivity. Results: 183 HIV-infected participants were enrolled, comprising children (n = 88), adolescents (n = 47) and pregnant women (n = 48). All participants (100%) were CMV IgG-positive, while 56.8%, 93.6% and 100% of children, adolescents and pregnant women, respectively, were HAV IgG-positive. The prevalence of HCV, HTLV-1/2 and syphilis were <4%. HBV markers were distributed as follows—children: HBsAg (2.3%), HBeAg (0%), anti-HBc (5.7%); adolescents: HBsAg (17.0%), HBeAg (6.4%), anti-HBc (27.7%); and pregnant women: HBsAg (18.8%), HBeAg (4.2%), anti-HBc (77.1%). Age >10 years, i.e., being born pre-2009 before implementation of routine hepatitis B immunization (aOR 5.05 [1.18−21.28]; p = 0.029) and CD4 count <350 cells/mm3 (aOR 3.97 [1.07−14.71]; p = 0.039) predicted HBsAg positivity. Conclusion: A high burden of chronic HBV and other endemic infections was observed among HIV-infected patients born pre-2009 before implementation of routine HBV immunization in Sierra Leone, warranting targeted screening and immunization of this high-risk population.
KW - CMV
KW - HIV
KW - HTLV
KW - Hepatitis viruses
KW - Sierra Leone
KW - Syphilis
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U2 - 10.1016/j.ijid.2020.09.1459
DO - 10.1016/j.ijid.2020.09.1459
M3 - Article
C2 - 33002619
AN - SCOPUS:85096207916
SN - 1201-9712
VL - 102
SP - 45
EP - 52
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -