Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F. Brun-Vézinet; C. Rouzioux; L. Montagnier; S. Chamaret; J. Gruest; F. Barré-Sinoussi; D. Geroldi; J. C. Chermann; J. Mccormick; S. Mitchell; P. Piot; H. Taelman; Kapita Bila Mirlangu; Odio Wobin; N. Mbendi; P. Mazebo; Kayembe Kalambayi; C. Bridts; J. Desmyter; F. M. Feinsod; T. C. Quinn

doi:10.1126/science.6238406

Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

F. Brun-Vézinet, C. Rouzioux, L. Montagnier, S. Chamaret, J. Gruest, F. Barré-Sinoussi, D. Geroldi, J. C. Chermann, J. Mccormick, S. Mitchell, P. Piot, H. Taelman, Kapita Bila Mirlangu, Odio Wobin, N. Mbendi, P. Mazebo, Kayembe Kalambayi, C. Bridts, J. Desmyter, F. M. FeinsodT. C. Quinn

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Abstract

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.

Original language	English (US)
Pages (from-to)	453-456
Number of pages	4
Journal	Science
Volume	226
Issue number	4673
DOIs	https://doi.org/10.1126/science.6238406
State	Published - Jan 1 1984
Externally published	Yes

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Brun-Vézinet, F., Rouzioux, C., Montagnier, L., Chamaret, S., Gruest, J., Barré-Sinoussi, F., Geroldi, D., Chermann, J. C., Mccormick, J., Mitchell, S., Piot, P., Taelman, H., Mirlangu, K. B., Wobin, O., Mbendi, N., Mazebo, P., Kalambayi, K., Bridts, C., Desmyter, J., ... Quinn, T. C. (1984). Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS. Science, 226(4673), 453-456. https://doi.org/10.1126/science.6238406

Brun-Vézinet, F, Rouzioux, C, Montagnier, L, Chamaret, S, Gruest, J, Barré-Sinoussi, F, Geroldi, D, Chermann, JC, Mccormick, J, Mitchell, S, Piot, P, Taelman, H, Mirlangu, KB, Wobin, O, Mbendi, N, Mazebo, P, Kalambayi, K, Bridts, C, Desmyter, J, Feinsod, FM & Quinn, TC 1984, 'Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS', Science, vol. 226, no. 4673, pp. 453-456. https://doi.org/10.1126/science.6238406

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title = "Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS",

abstract = "The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.",

author = "F. Brun-V{\'e}zinet and C. Rouzioux and L. Montagnier and S. Chamaret and J. Gruest and F. Barr{\'e}-Sinoussi and D. Geroldi and Chermann, {J. C.} and J. Mccormick and S. Mitchell and P. Piot and H. Taelman and Mirlangu, {Kapita Bila} and Odio Wobin and N. Mbendi and P. Mazebo and Kayembe Kalambayi and C. Bridts and J. Desmyter and Feinsod, {F. M.} and Quinn, {T. C.}",

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AU - Brun-Vézinet, F.

AU - Rouzioux, C.

AU - Montagnier, L.

AU - Chamaret, S.

AU - Gruest, J.

AU - Barré-Sinoussi, F.

AU - Geroldi, D.

AU - Chermann, J. C.

AU - Mccormick, J.

AU - Mitchell, S.

AU - Piot, P.

AU - Taelman, H.

AU - Mirlangu, Kapita Bila

AU - Wobin, Odio

AU - Mbendi, N.

AU - Mazebo, P.

AU - Kalambayi, Kayembe

AU - Bridts, C.

AU - Desmyter, J.

AU - Feinsod, F. M.

AU - Quinn, T. C.

PY - 1984/1/1

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AB - The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.

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Prevalence of antibodies to lymphadenopathy-associated retrovirus in African patients with AIDS

Abstract

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