TY - JOUR
T1 - Prevalence of 21-hydroxylase-deficient nonclassic adrenal hyperplasia and insulin resistance among hirsute women from Puerto Rico
AU - Romaguera, Josefina
AU - Moran, Carlos
AU - Diaz-Montes, Teresa P.
AU - Hines, Gene A.
AU - Cruz, Rosa I.
AU - Azziz, Ricardo
N1 - Funding Information:
Supported by grants RO1-HD29364 (Dr. Azziz) and RCMI Clinical Research Infrastructure Initiative Award, 1P20RR 11126, National Center for Research Resources, National Institutes of Health (Dr. Romaguera).
PY - 2000/7
Y1 - 2000/7
N2 - Objective: To determine the prevalence of 21-hydroxylase (21-OH)-deficient nonclassic adrenal hyperplasia (NCAH) and insulin resistance in hirsute women from Puerto Rico : Cross-sectional prospective study. Sett : Clinical research center. Patient(s): 100 consecutive untreated hirsute women. Main Outcome Measure(s): Fasting total T, free T, DHEAS, insulin, and glucose were measured, and a 60-minute acute ACTH-(1-24) stimulation for 17-hydroxyprogesterone (17-HP) was performed. A diagnosis of 21-OH-deficient NCAH was considered when the stimulated 17-HP level was >30.3 nmol/L. The glucose/insulin ratio was calculated as a measure of insulin resistance (normal value, ≥4.5). Result(s): Patients had a mean (±SD) age of 26.8 ± 6.6 years; 82 were oligomenorrheic. Overall, 12%, 8%, and 60% of patients had elevated levels of DHEAS, total T, or free T, respectively. One patient was identified as having 21-OH-deficient NCAH. Eight women, none of whom had NCAH, were found to be hyperglycemic; four of these women had type 2 diabetes mellitus. Excluding hyperglycemic patients, a glucose/insulin ratio of <4.5, consistent with IR, was found in 51.7%. Conclusion(s): The prevalence of 21-OH-deficient NCAH among patients from Puerto Rico does not differ significantly from that reported for other non-Jewish, non-Hispanic white populations. Copyright (C) 2000 American Society for Reproductive Medicine.
AB - Objective: To determine the prevalence of 21-hydroxylase (21-OH)-deficient nonclassic adrenal hyperplasia (NCAH) and insulin resistance in hirsute women from Puerto Rico : Cross-sectional prospective study. Sett : Clinical research center. Patient(s): 100 consecutive untreated hirsute women. Main Outcome Measure(s): Fasting total T, free T, DHEAS, insulin, and glucose were measured, and a 60-minute acute ACTH-(1-24) stimulation for 17-hydroxyprogesterone (17-HP) was performed. A diagnosis of 21-OH-deficient NCAH was considered when the stimulated 17-HP level was >30.3 nmol/L. The glucose/insulin ratio was calculated as a measure of insulin resistance (normal value, ≥4.5). Result(s): Patients had a mean (±SD) age of 26.8 ± 6.6 years; 82 were oligomenorrheic. Overall, 12%, 8%, and 60% of patients had elevated levels of DHEAS, total T, or free T, respectively. One patient was identified as having 21-OH-deficient NCAH. Eight women, none of whom had NCAH, were found to be hyperglycemic; four of these women had type 2 diabetes mellitus. Excluding hyperglycemic patients, a glucose/insulin ratio of <4.5, consistent with IR, was found in 51.7%. Conclusion(s): The prevalence of 21-OH-deficient NCAH among patients from Puerto Rico does not differ significantly from that reported for other non-Jewish, non-Hispanic white populations. Copyright (C) 2000 American Society for Reproductive Medicine.
KW - Adrenal hyperplasia
KW - Androgens
KW - Hirsutism
KW - Hyperandrogenism
KW - Insulin resistance
KW - Polycystic ovary syndrome
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U2 - 10.1016/S0015-0282(00)00566-5
DO - 10.1016/S0015-0282(00)00566-5
M3 - Article
C2 - 10899497
AN - SCOPUS:0033930855
SN - 0015-0282
VL - 74
SP - 59
EP - 62
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -