TY - JOUR
T1 - Prevalence and predictors of prior antibacterial use among patients presenting to hospitals in Northern Uganda
AU - Ocan, Moses
AU - Manabe, Yukari C.
AU - Baluku, Hannington
AU - Atukwase, Esther
AU - Ogwal-Okeng, Jasper
AU - Obua, Celestino
N1 - Funding Information:
The study recieved funding from grant number 5R34TW00886 supported by OGAC, NIH and HRSA. The funders did not play any part in the design, data collection, analysis or writing of the article.
Funding Information:
We would like to thank the administration of the two hospitals for accepting to grant laboratory space for this study and the entire laboratory staff of Lira and Gulu RRHs. We also thank OGAC, NIH and HRSA for the financial support offered through grant number 5R24TW008886.
Publisher Copyright:
© 2015 Ocan et al.
PY - 2015/9/25
Y1 - 2015/9/25
N2 - Background: Human antibacterial exposure occur in different ways including consumption of animal and agricultural products as well as use of prescribed and non-prescribed agents. We estimated the prevalence and explored the predictors of antibacterial use among patients presenting to hospitals in northern Uganda. Methods: Four hundred fifty (450) patients were randomly selected and antibacterial use prior to hospital visit measured using a questionnaire and urine antibacterial activity assay. Urine antibacterial bioassays were performed using American type culture collections of Escherichia coli, Bacillus subtilis and Streptococcus pyogenes. Data were analysed using STATA 12.0 at 95 % confidence level. Results: Of 450 patients interviewed, 62.2 % had used antibacterial agents. Urine antibacterial activity was detected in 30.4 % of the samples tested. Of the 85 patients who reported not taking any antibacterial at home, 16 (18.8 %) had urine with antibacterial activity. Most test bacteria, E. coli (74.5 %), B. subtilis (72.6 %) and S. pyogens (86.7 %) were sensitive to urine of patients who reported using antibacterial drugs before hospital visit. From the interview, metronidazole 15.6 % (70/450), amoxicillin 12 % (54/450), and ciprofloxacin 10.4 % (47/450) were the most used antibacterial agents. Patient age (OR, 2.45: 95 % CI: 1.02-5.91: P=0.024), time-lag between last drug intake and hospital visit (OR: 3.18: 95 % CI: 1.44-7.0: P<0.0001), and time-lag between illness onset and hospital visit (OR: 1.89: 95 % CI: 0.38-5.1: P=0.027) predicted the use of antibacterial agents before hospital visit. Discussion: Community antibacterial use continues to take place in an unregulated manner. In addition, physiciansrarely seek to ascertain prior use of antibacterial agents among patients presenting to hospitals. This couldhave a bearing on patient treatment outcomes. Conclusion: Knowledge of prior antibacterial use among patients presenting to hospitals is useful to physicians in ensuring antibacterial stewardship.
AB - Background: Human antibacterial exposure occur in different ways including consumption of animal and agricultural products as well as use of prescribed and non-prescribed agents. We estimated the prevalence and explored the predictors of antibacterial use among patients presenting to hospitals in northern Uganda. Methods: Four hundred fifty (450) patients were randomly selected and antibacterial use prior to hospital visit measured using a questionnaire and urine antibacterial activity assay. Urine antibacterial bioassays were performed using American type culture collections of Escherichia coli, Bacillus subtilis and Streptococcus pyogenes. Data were analysed using STATA 12.0 at 95 % confidence level. Results: Of 450 patients interviewed, 62.2 % had used antibacterial agents. Urine antibacterial activity was detected in 30.4 % of the samples tested. Of the 85 patients who reported not taking any antibacterial at home, 16 (18.8 %) had urine with antibacterial activity. Most test bacteria, E. coli (74.5 %), B. subtilis (72.6 %) and S. pyogens (86.7 %) were sensitive to urine of patients who reported using antibacterial drugs before hospital visit. From the interview, metronidazole 15.6 % (70/450), amoxicillin 12 % (54/450), and ciprofloxacin 10.4 % (47/450) were the most used antibacterial agents. Patient age (OR, 2.45: 95 % CI: 1.02-5.91: P=0.024), time-lag between last drug intake and hospital visit (OR: 3.18: 95 % CI: 1.44-7.0: P<0.0001), and time-lag between illness onset and hospital visit (OR: 1.89: 95 % CI: 0.38-5.1: P=0.027) predicted the use of antibacterial agents before hospital visit. Discussion: Community antibacterial use continues to take place in an unregulated manner. In addition, physiciansrarely seek to ascertain prior use of antibacterial agents among patients presenting to hospitals. This couldhave a bearing on patient treatment outcomes. Conclusion: Knowledge of prior antibacterial use among patients presenting to hospitals is useful to physicians in ensuring antibacterial stewardship.
KW - Antibacterial
KW - Northern Uganda
KW - Self-medication
KW - Self-report
KW - Urine antibacterial bioassay
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UR - http://www.scopus.com/inward/citedby.url?scp=84942156197&partnerID=8YFLogxK
U2 - 10.1186/s40360-015-0027-8
DO - 10.1186/s40360-015-0027-8
M3 - Article
C2 - 26407973
AN - SCOPUS:84942156197
SN - 2050-6511
VL - 16
JO - BMC Pharmacology and Toxicology
JF - BMC Pharmacology and Toxicology
IS - 1
M1 - 26
ER -