TY - JOUR
T1 - Prevalence and levels of antibodies to the circumsporozoite protein of plasmodium falciparum in an endemic area and their relationship to resistance against malaria infection
AU - Esposito, Fulvio
AU - Lombardi, Stefania
AU - Modiano, David
AU - Zavala, Fidel
AU - Reeme, Jan
AU - Lamizana, Lansina
AU - Coluzzi, Mario
AU - Nussenzweig, Ruth S.
N1 - Funding Information:
Acknowledgements It is a pleasure to thank Professor Sir Ian McGregor for critically reading the manuscript. We also gratefully acknowledge the excellent technical assistance of Silvana Bagalino in Rome and Simon-Pierre Zoneo and Benoit 1. Zoungrana in Ouagadougou. The skilled a&ninistrative work by-Sharon Hecht in New York was invaluable. This study received financial support from the Dipartimento per la Cooperazione allo Sviluppo-Minister0 Affari Esteri; The Rockefeller Foundation; Fondazione Istituto Pasteur-Cenci Bolognetti; the International Atomic Energy Agency; and WHOITDR Director’s Initiative Fund. Some of these results were preliminarily presented by F. E. at the 14th Conference of the Italian Society of Parasitologists, in Piss, 21-24 May, 1986.
PY - 1988/11/1
Y1 - 1988/11/1
N2 - A study on malaria transmission, prevalence of infection and anti-sporozoite antibodies was carried out in Burkina Faso (West Africa). The prevalence and the levels of antibodies to (NANP)3 were found to be related to the entomological sporozoite inoculation rates measured at the same time in a defined area. The major inducer of anti-(NANP)3 antibody production under field conditions is sporozoite inoculation by infected mosquitoes. Levels of antibodies to (NANP)3 vary considerably with age and transmission season. High levels of anti-(NANP)3 antibodies raised under field conditions might offer protection against small inocula of sporozoites.
AB - A study on malaria transmission, prevalence of infection and anti-sporozoite antibodies was carried out in Burkina Faso (West Africa). The prevalence and the levels of antibodies to (NANP)3 were found to be related to the entomological sporozoite inoculation rates measured at the same time in a defined area. The major inducer of anti-(NANP)3 antibody production under field conditions is sporozoite inoculation by infected mosquitoes. Levels of antibodies to (NANP)3 vary considerably with age and transmission season. High levels of anti-(NANP)3 antibodies raised under field conditions might offer protection against small inocula of sporozoites.
UR - http://www.scopus.com/inward/record.url?scp=0024263574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024263574&partnerID=8YFLogxK
U2 - 10.1016/0035-9203(88)90007-7
DO - 10.1016/0035-9203(88)90007-7
M3 - Article
C2 - 2908285
AN - SCOPUS:0024263574
SN - 0035-9203
VL - 82
SP - 827
EP - 832
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 6
ER -