Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty

Jimmy K. Lee; Allen O. Eghrari; Neel R. Desai; Walter J. Stark; John D. Gottsch

doi:10.1016/j.ajo.2008.09.026

Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty

Jimmy K. Lee, Allen O. Eghrari, Neel R. Desai, Walter J. Stark, John D. Gottsch

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Purpose: To present a novel method of reducing rates of graft detachment, the most common postoperative complication of Descemet stripping endothelial keratoplasty (DSEK). Design: Retrospective, interventional case series. Methods: Eighty-three consecutive patients undergoing DSEK for endothelial dystrophy were studied. DSEK was performed in 103 eyes by 2 surgeons (J.D.G. and W.J.S.) at one institution before (n = 83) and after (n = 20) presoaking donor grafts in balanced salt solution (BSS) Plus (Alcon, Fort Worth, Texas, USA). No significant change in the frequency of using other techniques was made during this time. Incidents of tissue detachment after surgery were recorded. Results: Of 83 consecutive DSEK procedures carried out before presoaking the donor tissue in BSS Plus, detachment occurred in 25 (30%). After presoaking, the detachment rate was reduced significantly to 0 (0%) of 20 (P = .0019). Conclusions: Patients undergoing DSEK experienced a significant decrease in rates of graft detachment after adoption of this new technique. The results suggest that presoaking donor tissue in BSS Plus lowers the detachment rate of DSEK grafts.

Original language	English (US)
Pages (from-to)	439-441.e2
Journal	American journal of ophthalmology
Volume	147
Issue number	3
DOIs	https://doi.org/10.1016/j.ajo.2008.09.026
State	Published - Mar 2009

ASJC Scopus subject areas

Ophthalmology

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@article{2961927249614ea0a742953d6c20c07f,

title = "Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty",

abstract = "Purpose: To present a novel method of reducing rates of graft detachment, the most common postoperative complication of Descemet stripping endothelial keratoplasty (DSEK). Design: Retrospective, interventional case series. Methods: Eighty-three consecutive patients undergoing DSEK for endothelial dystrophy were studied. DSEK was performed in 103 eyes by 2 surgeons (J.D.G. and W.J.S.) at one institution before (n = 83) and after (n = 20) presoaking donor grafts in balanced salt solution (BSS) Plus (Alcon, Fort Worth, Texas, USA). No significant change in the frequency of using other techniques was made during this time. Incidents of tissue detachment after surgery were recorded. Results: Of 83 consecutive DSEK procedures carried out before presoaking the donor tissue in BSS Plus, detachment occurred in 25 (30%). After presoaking, the detachment rate was reduced significantly to 0 (0%) of 20 (P = .0019). Conclusions: Patients undergoing DSEK experienced a significant decrease in rates of graft detachment after adoption of this new technique. The results suggest that presoaking donor tissue in BSS Plus lowers the detachment rate of DSEK grafts.",

author = "Lee, {Jimmy K.} and Eghrari, {Allen O.} and Desai, {Neel R.} and Stark, {Walter J.} and Gottsch, {John D.}",

note = "Funding Information: This study was supported by the National Eye Institute, Washington, DC Grant R01 Ey016835 (Dr Gottsch). The authors indicate no financial conflict of interest. Involved in design of study (J.K.L., J.D.G., W.J.S., N.R.D.); conduct of study (J.K.L., J.D.G., W.J.S., N.R.D., A.O.E.); collection, management, analysis, and interpretation of data (J.K.L., A.O.E., J.D.G., W.J.S., N.R.D.); and preparation, review, and approval of the manuscript (J.K.L., J.D.G., A.O.E., N.R.D., W.J.S.). The study protocol was approved by the Joint Committee on Clinical Investigation at the Johns Hopkins University School of Medicine and was in accordance with the tenets of the Declaration of Helsinki. The study is in accordance with Health Insurance Portability and Accountability Act regulations. Written informed consent was obtained from all study participants for treatment and participation in the research. ",

year = "2009",

month = mar,

doi = "10.1016/j.ajo.2008.09.026",

language = "English (US)",

volume = "147",

pages = "439--441.e2",

journal = "American journal of ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "3",

}

TY - JOUR

T1 - Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty

AU - Lee, Jimmy K.

AU - Eghrari, Allen O.

AU - Desai, Neel R.

AU - Stark, Walter J.

AU - Gottsch, John D.

N1 - Funding Information: This study was supported by the National Eye Institute, Washington, DC Grant R01 Ey016835 (Dr Gottsch). The authors indicate no financial conflict of interest. Involved in design of study (J.K.L., J.D.G., W.J.S., N.R.D.); conduct of study (J.K.L., J.D.G., W.J.S., N.R.D., A.O.E.); collection, management, analysis, and interpretation of data (J.K.L., A.O.E., J.D.G., W.J.S., N.R.D.); and preparation, review, and approval of the manuscript (J.K.L., J.D.G., A.O.E., N.R.D., W.J.S.). The study protocol was approved by the Joint Committee on Clinical Investigation at the Johns Hopkins University School of Medicine and was in accordance with the tenets of the Declaration of Helsinki. The study is in accordance with Health Insurance Portability and Accountability Act regulations. Written informed consent was obtained from all study participants for treatment and participation in the research.

PY - 2009/3

Y1 - 2009/3

N2 - Purpose: To present a novel method of reducing rates of graft detachment, the most common postoperative complication of Descemet stripping endothelial keratoplasty (DSEK). Design: Retrospective, interventional case series. Methods: Eighty-three consecutive patients undergoing DSEK for endothelial dystrophy were studied. DSEK was performed in 103 eyes by 2 surgeons (J.D.G. and W.J.S.) at one institution before (n = 83) and after (n = 20) presoaking donor grafts in balanced salt solution (BSS) Plus (Alcon, Fort Worth, Texas, USA). No significant change in the frequency of using other techniques was made during this time. Incidents of tissue detachment after surgery were recorded. Results: Of 83 consecutive DSEK procedures carried out before presoaking the donor tissue in BSS Plus, detachment occurred in 25 (30%). After presoaking, the detachment rate was reduced significantly to 0 (0%) of 20 (P = .0019). Conclusions: Patients undergoing DSEK experienced a significant decrease in rates of graft detachment after adoption of this new technique. The results suggest that presoaking donor tissue in BSS Plus lowers the detachment rate of DSEK grafts.

AB - Purpose: To present a novel method of reducing rates of graft detachment, the most common postoperative complication of Descemet stripping endothelial keratoplasty (DSEK). Design: Retrospective, interventional case series. Methods: Eighty-three consecutive patients undergoing DSEK for endothelial dystrophy were studied. DSEK was performed in 103 eyes by 2 surgeons (J.D.G. and W.J.S.) at one institution before (n = 83) and after (n = 20) presoaking donor grafts in balanced salt solution (BSS) Plus (Alcon, Fort Worth, Texas, USA). No significant change in the frequency of using other techniques was made during this time. Incidents of tissue detachment after surgery were recorded. Results: Of 83 consecutive DSEK procedures carried out before presoaking the donor tissue in BSS Plus, detachment occurred in 25 (30%). After presoaking, the detachment rate was reduced significantly to 0 (0%) of 20 (P = .0019). Conclusions: Patients undergoing DSEK experienced a significant decrease in rates of graft detachment after adoption of this new technique. The results suggest that presoaking donor tissue in BSS Plus lowers the detachment rate of DSEK grafts.

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JO - American journal of ophthalmology

JF - American journal of ophthalmology

IS - 3

ER -

Presoaking Donor Corneas Reduces Graft Detachment Rates in Descemet Stripping Endothelial Keratoplasty

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