Preservation of hippocampal volume throughout adulthood in healthy men and women

Edith V. Sullivan, Laura Marsh, Adolf Pfefferbaum

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


To address controversies regarding the effect of age on the hippocampus, volumes of hippocampus and a comparison structure, temporal cortex, were measured on magnetic resonance imaging (MRI) in 84 healthy men and 44 healthy women (20-85 years). Neither men nor women showed significant correlations between hippocampal volumes and age, despite significant age-related decline in temporal volumes. Absence of hippocampus age relationships endured when restricting analyses to older individuals (≥50 years) and considering menopause and hormone replacement therapy.

Original languageEnglish (US)
Pages (from-to)1093-1098
Number of pages6
JournalNeurobiology of Aging
Issue number7
StatePublished - Jul 2005


  • Adulthood
  • Hippocampal volume
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • General Psychology


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