@article{1ef1ccaf8e1d4f6d904ef27ea93e2563,
title = "Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia",
abstract = "More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasmsthe most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.",
keywords = "Neoplasm, Pancreatic Cancer, Transformation, Tumorigenesis",
author = "Mitsuro Kanda and Hanno Matthaei and Jian Wu and Hong, {Seung Mo} and Jun Yu and Michael Borges and Hruban, {Ralph H.} and Anirban Maitra and Kenneth Kinzler and Bert Vogelstein and Michael Goggins",
note = "Funding Information: Funding This work was supported by National Institutes of Health grants ( CA62924 , R01CA97075 , R01CA120432 , RC2CA148376 , and P01CA134292 ), the Stringer Foundation, the Michael Rolfe Foundation, the Lustgarten Foundation for pancreatic cancer research, and German Cancer Aid (Deutsche Krebshilfe e.V.). ",
year = "2012",
month = apr,
doi = "10.1053/j.gastro.2011.12.042",
language = "English (US)",
volume = "142",
pages = "730--733.e9",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",
}