Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia

Mitsuro Kanda, Hanno Matthaei, Jian Wu, Seung Mo Hong, Jun Yu, Michael Borges, Ralph H. Hruban, Anirban Maitra, Kenneth Kinzler, Bert Vogelstein, Michael Goggins

Research output: Contribution to journalArticlepeer-review

390 Scopus citations


More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasmsthe most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.

Original languageEnglish (US)
Pages (from-to)730-733.e9
Issue number4
StatePublished - Apr 2012


  • Neoplasm
  • Pancreatic Cancer
  • Transformation
  • Tumorigenesis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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