Presence of haptoglobin-2 allele is associated with worse functional outcomes after spontaneous intracerebral hemorrhage

Santosh B. Murthy, Andrew P. Levy, Joshua Duckworth, Eric B. Schneider, Hadar Shalom, Daniel F. Hanley, Rafael J. Tamargo, Paul A. Nyquist

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


OBJECTIVE: To determine if the haptoglobin (Hp) phenotype, which has been shown to be a predictor of clinical outcomes in cerebrovascular disorders, particularly subarachnoid hemorrhage, was predictive of functional outcomes after spontaneous intracerebral hemorrhage (ICH). -METHODS: Patients admitted with a diagnosis of ICH were prospectively included and divided into 3 groups based on their genetically determined Hp phenotype: 1-1, 2-1, and 2-2. Outcome measures included mortality and 30-day modified Rankin Scale scores. Demographics and outcomes were compared for each phenotype using multivariate linear regression analysis. -RESULTS: The study included 94 patients. The distribution of Hp phenotype was Hp 1-1, 12 (13%); Hp 2-1, 46 (49%); and Hp 2-2, 36 (38%). The 3 Hp subgroups did not differ in terms of demographic variables, comorbidities, or ICH characteristics. There was a nonsignificant trend toward increased mortality in Hp 2-1 and Hp 2-2 compared with Hp 1-1, with mortality of 8% in Hp 1-1, 17% in Hp 2-1, and 25% in Hp 2-2 (P [0.408). In the regression model adjusted for confounders, Hp 2-1 (odds ratio [ 0.05, 95% confidence interval [ 0.01e0.47, P < 0.001) and Hp 2-2 phenotypes (odds ratio [ 0.14, 95% confidence interval [ 0.02e0.86, P [ 0.045) had significantly lower odds of modified Rankin Scale scores 0e2 compared with Hp 1-1. -CONCLUSIONS: After ICH, individuals with the Hp-2 allele (2-1 and 2-2) had worse functional outcomes than individuals with the Hp-1 allele (Hp 1-1). There was a nonsignificant association between Hp phenotype and mortality. Larger prospective studies with better surrogates of ICH outcomes are warranted.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalWorld neurosurgery
Issue number4
StatePublished - 2015


  • Clinical outcomes
  • Haptoglobin phenotype
  • Intracerebral hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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