TY - JOUR
T1 - Presence of Antibodies to Simian Virus 40 (SV40) T Antigen in Rhesus Monkeys Infected Experimentally or Naturally with SV40
AU - Shah, K. V.
AU - Hess, D. M.
N1 - Funding Information:
Supported by Grant E440 from American Cancer Society, Grant 507 TW00141-47 CIC from USPHS to The Johns Hopkins Center for Medical Research and Training, and by contract no. 43-63-25 with the National Institutes of Health, Public Health Service, Department of Health, Education and Welfare. 6 1968 128 2 480 485
PY - 1968/6
Y1 - 1968/6
N2 - All of 16 rhesus infected with SV40 by i.n., s.c., or i.g. inoculation developed neutralizing antibodies by the third week after inoculation. All of 10 animals infected by s.c. or i.g. route and a majority of those by the i.n. route were viremic. Viremia titers were higher in the group inoculated s.c. The T antibodies developed in all except two in the i.n. inoculated group. The T antibodies appeared earlier, reached higher peaks, and persisted longer after s.c. inoculation as compared to after i.n. inoculation. The T antibodies were detected in a proportion of naturally infected rhesus. This proportion was highest (85%) in 1-2 year old rhesus and declined with increase in age of donor.
AB - All of 16 rhesus infected with SV40 by i.n., s.c., or i.g. inoculation developed neutralizing antibodies by the third week after inoculation. All of 10 animals infected by s.c. or i.g. route and a majority of those by the i.n. route were viremic. Viremia titers were higher in the group inoculated s.c. The T antibodies developed in all except two in the i.n. inoculated group. The T antibodies appeared earlier, reached higher peaks, and persisted longer after s.c. inoculation as compared to after i.n. inoculation. The T antibodies were detected in a proportion of naturally infected rhesus. This proportion was highest (85%) in 1-2 year old rhesus and declined with increase in age of donor.
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U2 - 10.3181/00379727-128-33043
DO - 10.3181/00379727-128-33043
M3 - Article
C2 - 4298701
AN - SCOPUS:0014298937
SN - 0037-9727
VL - 128
SP - 480
EP - 485
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
IS - 2
ER -