Presence of Antibodies to Simian Virus 40 (SV40) T Antigen in Rhesus Monkeys Infected Experimentally or Naturally with SV40

All of 16 rhesus infected with SV40 by i.n., s.c., or i.g. inoculation developed neutralizing antibodies by the third week after inoculation. All of 10 animals infected by s.c. or i.g. route and a majority of those by the i.n. route were viremic. Viremia titers were higher in the group inoculated s.c. The T antibodies developed in all except two in the i.n. inoculated group. The T antibodies appeared earlier, reached higher peaks, and persisted longer after s.c. inoculation as compared to after i.n. inoculation. The T antibodies were detected in a proportion of naturally infected rhesus. This proportion was highest (85%) in 1-2 year old rhesus and declined with increase in age of donor.