@article{d696d8fd88dc416291622951503cf0fd,
title = "Prescription patterns of opioids and non-steroidal anti-inflammatory drugs in the first year after living kidney donation: An analysis of U.S. Registry and Pharmacy fill records",
abstract = "We examined a novel database linking national donor registry identifiers to records from a US pharmaceutical claims warehouse (2007-2015) to describe opioid and NSAID prescription patterns among LKDs during the first year postdonation, divided into three periods: 0-14 days, 15-182 days, and 183-365 days. Associations of opioid and NSAID prescription fills with baseline factors were examined by logistic regression (adjusted odds ratio, LCLaORUCL). Among 23,565 donors, opioid prescriptions were highest during days 0-14 (36.6%), but 12.6% of donors filled opioids during days 183-365. NSAID prescriptions rose from 0.5% during days 0-14 to 3.3% during days 183-365. Women filled opioids more commonly than men, and black donors filled both opioids and NSAIDs more commonly than white donors. After covariate adjustment, significant correlates of opioid prescription fills during days 183-365 included obesity (aOR,1.241.381.53), less than college education (aOR,1.191.311.43), smoking (aOR,1.331.451.58), and nephrectomy complications (aOR,1.111.291.49). NSAID prescription fills in year 1 were not associated with differences in estimated glomerular filtration rate, incidence of proteinuria or new-onset hypertension at the first and second year postdonation. Prescription fills for opioids and NSAIDs for LKDs varied with demographic and clinic traits. Future work should examine longer-term outcome implications to help inform safe analgesic regimen choices after donation.",
keywords = "donors and donation, epidemiology, living kidney donor, pain management, pharmacy records, registries",
author = "Vest, {Luke S.} and Nagaraju Sarabu and Koraishy, {Farrukh M.} and Nguyen, {Minh Tri} and Meyeon Park and Lam, {Ngan N.} and Schnitzler, {Mark A.} and David Axelrod and Hsu, {Chi Yuan} and Garg, {Amit X.} and Segev, {Dorry L.} and Massie, {Allan B.} and Hess, {Gregory P.} and Kasiske, {Bertram L.} and Lentine, {Krista L.}",
note = "Funding Information: This work was conducted under the auspices of the Hennepin Healthcare Research Institute, contractor for the Scientific Registry of Transplant Recipients (SRTR), as a deliverable under contract no. HHSH250201000018C (US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation). The US Government (and others acting on its behalf) retains a paid-up, non-exclusive, irrevocable, worldwide license for all works produced under the SRTR contract, and to reproduce them, prepare derivative works, distribute copies to the public, and perform publicly and display publicly, by or on behalf of the Government. The data reported here have been supplied by HHRI as the contractor for SRTR. The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the US Government. MP, MAS, CYH, and KLL receive support from grant from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK120551. KLL receives support as the Mid-America Transplant/Jane A. Beckman Endowed Chair in Transplantation. An abstract describing portions of this work was presented at the 2019 American Transplant Congress, Boston, MA. The opinions, results, and conclusions reported in this article are those of the authors and are independent of the funding sources. The authors thank SRTR colleague Nan Booth, MSW, MPH, and ELS, for manuscript editing. Funding Information: MP, MAS, CYH, and KLL receive support from grant from the National Institutes of Health (NIH)/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK120551. KLL receives support as the Mid‐America Transplant/Jane A. Beckman Endowed Chair in Transplantation. An abstract describing portions of this work was presented at the 2019 American Transplant Congress, Boston, MA. The opinions, results, and conclusions reported in this article are those of the authors and are independent of the funding sources. The authors thank SRTR colleague Nan Booth, MSW, MPH, and ELS, for manuscript editing. Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2020",
month = aug,
day = "1",
doi = "10.1111/ctr.14000",
language = "English (US)",
volume = "34",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "8",
}