Preparation, stability and acidity of difluoromethylene bis phosphonic acid

D. J. Burton, D. J. Pietrzyk, T. Ishihara, T. Fonong, R. M. Flynn

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Hydrolysis of difluoromethylene phosphonate esters quantitatively yields difluoromethylene bis phosphonic acid as a dihydrate. In vacuo drying leads to either the monohydrate or the anhydrous acid. Titration of either the free acid or its disodium salt and computer fit of the data gives all four pKas. The disodium salt and the free acid are thermally stable, and the disodium salt is extremely stable even to strong base.

Original languageEnglish (US)
Pages (from-to)617-626
Number of pages10
JournalJournal of Fluorine Chemistry
Issue number5
StatePublished - Jul 1982

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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