Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.

Timothy R. Kuklo; H. Thomas Temple; Brett D. Owens; John Juliano; Richard B. Islinger; Yvonne Andejeski; Deborah A. Frassica; B. Hudson Berrey

Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.

Timothy R. Kuklo, H. Thomas Temple, Brett D. Owens, John Juliano, Richard B. Islinger, Yvonne Andejeski, Deborah A. Frassica, B. Hudson Berrey

School of Medicine

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30 Scopus citations

Abstract

In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.

Original language	English (US)
Pages (from-to)	75-80
Number of pages	6
Journal	American journal of orthopedics (Belle Mead, N.J.)
Volume	34
Issue number	2
State	Published - Feb 2005

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.",

abstract = "In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.",

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AU - Kuklo, Timothy R.

AU - Temple, H. Thomas

AU - Owens, Brett D.

AU - Juliano, John

AU - Islinger, Richard B.

AU - Andejeski, Yvonne

AU - Frassica, Deborah A.

AU - Berrey, B. Hudson

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AB - In this article, we report results from a retrospective consecutive series of 117 patients with soft-tissue sarcomas treated with adjuvant radiation and surgical resection at 2 associated institutions. Fifty-nine patients received preoperative radiation; 58 patients received postoperative radiation. Mean clinical follow-ups were 6.1 years and 8.4 years, respectively. Nineteen (32.2%) of 59 patients in the preoperative group and 17 (29.3%) of 58 patients in the postoperative group had wound complications (P = .89). Three (5.1%) of 59 sarcomas in the preoperative group and 7 (12.1%) of 58 sarcomas in the postoperative group recurred locally (P = .19). Improved local disease control and other potential advantages of using preoperative radiation make this a preferred adjuvant treatment.

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Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.

Abstract

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