Prenatal identification of small mosaic markers of different chromosomal origins

Gail Stetten; Karin J. Blakemore; Anne M. Courter; Cathleen A. Coss; Ethylin Wang Jabs

doi:10.1002/pd.1970120203

Prenatal identification of small mosaic markers of different chromosomal origins

Gail Stetten, Karin J. Blakemore, Anne M. Courter, Cathleen A. Coss, Ethylin Wang Jabs

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.

Original language	English (US)
Pages (from-to)	83-91
Number of pages	9
Journal	Prenatal Diagnosis
Volume	12
Issue number	2
DOIs	https://doi.org/10.1002/pd.1970120203
State	Published - Feb 1992

Keywords

Centromeric probes
In situ hybridization
Marker chromosome

ASJC Scopus subject areas

Obstetrics and Gynecology
Genetics(clinical)

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10.1002/pd.1970120203

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title = "Prenatal identification of small mosaic markers of different chromosomal origins",

abstract = "In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.",

keywords = "Centromeric probes, In situ hybridization, Marker chromosome",

author = "Gail Stetten and Blakemore, {Karin J.} and Courter, {Anne M.} and Coss, {Cathleen A.} and Jabs, {Ethylin Wang}",

year = "1992",

month = feb,

doi = "10.1002/pd.1970120203",

language = "English (US)",

volume = "12",

pages = "83--91",

journal = "Prenatal Diagnosis",

issn = "0197-3851",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - Prenatal identification of small mosaic markers of different chromosomal origins

AU - Stetten, Gail

AU - Blakemore, Karin J.

AU - Courter, Anne M.

AU - Coss, Cathleen A.

AU - Jabs, Ethylin Wang

PY - 1992/2

Y1 - 1992/2

N2 - In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.

AB - In situ hybridization using a series of alphoid DNA probes has demonstrated the origin of two small accessory mosaic marker chromosomes ascertained from 1079 amniocenteses. These markers appeared to be de novo, derived from acrocentric chromosomes, and identical by traditional cytogenetic staining (G, Q, C, AgNOR, Hoechst‐distamycin). Molecular characterization showed that one marker had originated from chromosome 14, the other from chromosome 22. Clinical outcome in both cases was normal.

KW - Centromeric probes

KW - In situ hybridization

KW - Marker chromosome

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UR - http://www.scopus.com/inward/citedby.url?scp=0026534610&partnerID=8YFLogxK

U2 - 10.1002/pd.1970120203

DO - 10.1002/pd.1970120203

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AN - SCOPUS:0026534610

SN - 0197-3851

VL - 12

SP - 83

EP - 91

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 2

ER -

Prenatal identification of small mosaic markers of different chromosomal origins

Abstract

Keywords

ASJC Scopus subject areas

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