Prenatal diagnosis by transabdominal chorionic villus sampling in the second and third trimesters

T. M. Ko, L. H. Tseng, H. L. Hwa, T. Y. Lee, S. M. Chuang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


From October 1989 through December 1993, 124 pregnant women (114 in the second trimester and 10 in the third trimester) underwent transabdominal chorionic villus sampling (CVS) for prenatal molecular or cytogenetic diagnosis. The mean gestational age was 18.2 weeks. Indications for CVS comprised single gene disease (72%), fetal anomalies detected by ultrasound (17%), advanced maternal age (6%), and previous siblings with chromosomal aberration (5%). Among the 89 fetuses at risk for single gene disease, 20 were diagnosed as affected by DNA analysis. Among the 35 fetuses at risk for chromosomal anomaly, 4 had trisomy, 3 had a 45, XO karyotype and 2 had a structural chromosomal abnormality. The miscarriage rate was 1.8% (2/114) and the spontaneous preterm birth rate was 2.4% (3/124). No maternal or other fetal complications occurred. This study suggested that second- and third trimester CVS is a safe and useful method for prenatal diagnosis.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalArchives of Gynecology and Obstetrics
Issue number4
StatePublished - Dec 1995
Externally publishedYes


  • Chorionic villus sampling
  • Chromosome anomaly
  • Prenatal diagnosis
  • Single gene disease

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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