Prenatal and postnatal markers of severity in congenital diaphragmatic hernia have similar prognostic ability

N. L. Werner, M. Coughlin, S. M. Kunisaki, R. Hirschl, M. Ladino-Torres, D. Berman, J. Kreutzman, G. B. Mychaliska

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objectives: The purpose of this study was to compare prenatal versus postnatal markers of congenital diaphragmatic hernia (CDH) severity at a single fetal-care center. Methods: A retrospective study was performed of patients having a complete prenatal evaluation and surgical repair (n=55). Observed-to-expected lung-to-head ratio (o/eLHR), observed-to-expected total lung volume (o/eTLV), liver position (LP), a predictive dependent variable from logistic regression of o/eLHR and liver position (o/eLHR+LP), and diaphragmatic defect size per the CDH Study Group A-D classification were plotted into receiver-operating characteristics (ROC) curves. Survival and need for extracorporeal membrane oxygenation (ECMO) were primary outcomes. Results: Survival was 69%, and ECMO utilization was 56%. Distribution was 80% left-sided defects. In the survival ROC curve, the area under the curve (AUC) for o/eLHR was 0.73, o/eTLV 0.74, LP 0.73, o/eLHR+LP 0.78, and defect size 0.84 (p=0.23). The ROC curve for ECMO support showed o/eLHR had an AUC of 0.82, o/eTLV 0.89, LP 0.79, o/eLHR+LP 0.87, and defect size 0.90 (p=0.19). The AUCs were similar when only left-sided CDH was analyzed. Conclusions: These data suggest that prenatal evaluation was equivalent to the postnatal diaphragmatic defect classification for predicting survival and need for ECMO in CDH patients.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalPrenatal Diagnosis
Issue number2
StatePublished - Feb 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Genetics(clinical)


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