Premarin-induced ischemic colitis

Ahmet K. Gurbuz, Birgul Gurbuz, Louis Salas, Neil B. Rosenshein, Mark Donowitz, Francis M. Giardiello

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


There are numerous literature reports of oral contraceptive-induced (estrogen and progesterone) ischemic bowel disease. However, Premarin-induced (equine conjugated estrogen) intestinal ischemia has rarely been reported. We describe three cases of Premarin-induced ischemic colitis. In contrast to oral contraceptive-induced ischemic colitis, Premarin-induced ischemia is restricted to the colon, has not required surgical therapy, can have a chronic or chronic intermittent course, may be reversible despite continued usage of Premarin, and may present with nonspecific abdominal and colonic symptoms.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalJournal of clinical gastroenterology
Issue number2
StatePublished - Sep 1994


  • Colitis
  • Estrogen
  • Ischemia

ASJC Scopus subject areas

  • Gastroenterology


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