Preliminary trial of poly ICLC in chronic progressive multiple sclerosis

C. T. Bever; A. M. Salazar; E. Neely; B. E. Ferraraccio; J. W. Rose; H. F. McFarland; H. B. Levy; D. E. McFarlin

Preliminary trial of poly ICLC in chronic progressive multiple sclerosis

C. T. Bever, A. M. Salazar, E. Neely, B. E. Ferraraccio, J. W. Rose, H. F. McFarland, H. B. Levy, D. E. McFarlin

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Abstract

Eighteen patients with chronic progressive multiple sclerosis (MS) were treated in an open preliminary trial of the interferon inducer and immune modulator, poly ICLC. All patients produced substantial interferon levels and experienced acute side effects, including fever and transient worsening of neurologic symptoms. Of nine patients with rapid neurologic deterioration at the time of entry into the study, only three had disease progression during treatment. We conclude that poly ICLC can be administered safely to MS patients, and that a controlled trial will be necessary to determine efficacy.

Original language	English (US)
Pages (from-to)	494-498
Number of pages	5
Journal	Neurology
Volume	36
Issue number	4
State	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

Cite this

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title = "Preliminary trial of poly ICLC in chronic progressive multiple sclerosis",

abstract = "Eighteen patients with chronic progressive multiple sclerosis (MS) were treated in an open preliminary trial of the interferon inducer and immune modulator, poly ICLC. All patients produced substantial interferon levels and experienced acute side effects, including fever and transient worsening of neurologic symptoms. Of nine patients with rapid neurologic deterioration at the time of entry into the study, only three had disease progression during treatment. We conclude that poly ICLC can be administered safely to MS patients, and that a controlled trial will be necessary to determine efficacy.",

author = "Bever, {C. T.} and Salazar, {A. M.} and E. Neely and Ferraraccio, {B. E.} and Rose, {J. W.} and McFarland, {H. F.} and Levy, {H. B.} and McFarlin, {D. E.}",

year = "1986",

language = "English (US)",

volume = "36",

pages = "494--498",

journal = "Neurology",

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T1 - Preliminary trial of poly ICLC in chronic progressive multiple sclerosis

AU - Bever, C. T.

AU - Salazar, A. M.

AU - Neely, E.

AU - Ferraraccio, B. E.

AU - Rose, J. W.

AU - McFarland, H. F.

AU - Levy, H. B.

AU - McFarlin, D. E.

PY - 1986

Y1 - 1986

N2 - Eighteen patients with chronic progressive multiple sclerosis (MS) were treated in an open preliminary trial of the interferon inducer and immune modulator, poly ICLC. All patients produced substantial interferon levels and experienced acute side effects, including fever and transient worsening of neurologic symptoms. Of nine patients with rapid neurologic deterioration at the time of entry into the study, only three had disease progression during treatment. We conclude that poly ICLC can be administered safely to MS patients, and that a controlled trial will be necessary to determine efficacy.

AB - Eighteen patients with chronic progressive multiple sclerosis (MS) were treated in an open preliminary trial of the interferon inducer and immune modulator, poly ICLC. All patients produced substantial interferon levels and experienced acute side effects, including fever and transient worsening of neurologic symptoms. Of nine patients with rapid neurologic deterioration at the time of entry into the study, only three had disease progression during treatment. We conclude that poly ICLC can be administered safely to MS patients, and that a controlled trial will be necessary to determine efficacy.

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M3 - Article

C2 - 3960323

AN - SCOPUS:0022526911

SN - 0028-3878

VL - 36

SP - 494

EP - 498

JO - Neurology

JF - Neurology

IS - 4

ER -

Preliminary trial of poly ICLC in chronic progressive multiple sclerosis

Abstract

ASJC Scopus subject areas

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