Preliminary report on cognitive and adaptive behaviors of preschool-aged males with fragile X

L. S. Freund, C. D. Peebles, E. Aylward, A. L. Reiss

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Preliminary results are presented of 18 males with fragile X (fra X) syndrome between the ages of 16 and 64 months compared to non-fra X males individually matched on age and overall IQ. Cognitive assessments were conducted with either the Bayley Scales of Infant Development or the Stanford-Binet, 4th edition. Adaptive and maladaptive behaviors were assessed by the Vineland Adaptive Behavior Scales and the Child Behavior Checklist, respectively. Forty-four percent of the fra X group had overall IQs in the borderline to average ranges. In cognitive assessments with the Stanford-Binet, the fra X group scored lower than controls in quantitative and short-term memory areas. There was no evidence, however, that overall IQ declined among the fra X children across the 16 through 64 month age period. Older (≥ 40 months) fra X males scored lower in the communication and socialization adaptive behavior domains than younger (< 40 months) fra X males and older controls. Among maladaptive behaviors, social withdrawal behaviors were most problematic for the young males with fra X. These preliminary findings indicate that a neurobehavioral profile in fra X males was observed as early as 3-5 years of age and adaptive behavior development appeared to slow during this same age period.

Original languageEnglish (US)
Pages (from-to)242-251
Number of pages10
JournalDevelopmental Brain Dysfunction
Issue number4-6
StatePublished - Dec 1 1995
Externally publishedYes


  • IQ
  • age preschool
  • behaviors cognitive, adaptive
  • fragile X

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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