Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

Meredith P. Provost; Kelly S. Acharya; Chaitanya R. Acharya; Jason S. Yeh; Ryan G. Steward; Jennifer L. Eaton; James M. Goldfarb; Suheil J. Muasher

doi:10.1016/j.fertnstert.2015.10.015

Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

Meredith P. Provost, Kelly S. Acharya, Chaitanya R. Acharya, Jason S. Yeh, Ryan G. Steward, Jennifer L. Eaton, James M. Goldfarb, Suheil J. Muasher

School of Medicine

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Objective To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 22,317 donor oocyte cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5–24.9) were used as the reference group. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate. Result(s) Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased. Conclusion(s) Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.

Original language	English (US)
Pages (from-to)	364-368
Number of pages	5
Journal	Fertility and sterility
Volume	105
Issue number	2
DOIs	https://doi.org/10.1016/j.fertnstert.2015.10.015
State	Published - Feb 1 2016

Keywords

BMI
IVF
Obesity
donor
recipient
success rates

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

Access to Document

10.1016/j.fertnstert.2015.10.015

Fingerprint

Dive into the research topics of 'Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry'. Together they form a unique fingerprint.

Cite this

Provost, M. P., Acharya, K. S., Acharya, C. R., Yeh, J. S., Steward, R. G., Eaton, J. L., Goldfarb, J. M., & Muasher, S. J. (2016). Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry. Fertility and sterility, 105(2), 364-368. https://doi.org/10.1016/j.fertnstert.2015.10.015

Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry. / Provost, Meredith P.; Acharya, Kelly S.; Acharya, Chaitanya R. et al.
In: Fertility and sterility, Vol. 105, No. 2, 01.02.2016, p. 364-368.

Research output: Contribution to journal › Article › peer-review

Provost, MP, Acharya, KS, Acharya, CR, Yeh, JS, Steward, RG, Eaton, JL, Goldfarb, JM & Muasher, SJ 2016, 'Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry', Fertility and sterility, vol. 105, no. 2, pp. 364-368. https://doi.org/10.1016/j.fertnstert.2015.10.015

Provost MP, Acharya KS, Acharya CR, Yeh JS, Steward RG, Eaton JL et al. Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry. Fertility and sterility. 2016 Feb 1;105(2):364-368. doi: 10.1016/j.fertnstert.2015.10.015

@article{ffac9cd925ec45b99dfe22c1c377068e,

title = "Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry",

abstract = "Objective To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 22,317 donor oocyte cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5–24.9) were used as the reference group. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate. Result(s) Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased. Conclusion(s) Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.",

keywords = "BMI, IVF, Obesity, donor, recipient, success rates",

author = "Provost, {Meredith P.} and Acharya, {Kelly S.} and Acharya, {Chaitanya R.} and Yeh, {Jason S.} and Steward, {Ryan G.} and Eaton, {Jennifer L.} and Goldfarb, {James M.} and Muasher, {Suheil J.}",

note = "Publisher Copyright: {\textcopyright} 2016 American Society for Reproductive Medicine",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.fertnstert.2015.10.015",

language = "English (US)",

volume = "105",

pages = "364--368",

journal = "Fertility and sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Pregnancy outcomes decline with increasing recipient body mass index

T2 - an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

AU - Provost, Meredith P.

AU - Acharya, Kelly S.

AU - Acharya, Chaitanya R.

AU - Yeh, Jason S.

AU - Steward, Ryan G.

AU - Eaton, Jennifer L.

AU - Goldfarb, James M.

AU - Muasher, Suheil J.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 22,317 donor oocyte cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5–24.9) were used as the reference group. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate. Result(s) Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased. Conclusion(s) Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.

AB - Objective To examine the effect of recipient body mass index (BMI) on IVF outcomes in fresh donor oocyte cycles. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 22,317 donor oocyte cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry were stratified into cohorts based on World Health Organization BMI guidelines. Cycles reporting normal recipient BMI (18.5–24.9) were used as the reference group. Intervention(s) None. Main Outcome Measure(s) Implantation rate, clinical pregnancy rate (PR), pregnancy loss rate, live birth rate. Result(s) Success rates and adjusted odds ratios with 95% confidence intervals for all pregnancy outcomes were most favorable in cohorts of recipients with low and normal BMI, but progressively worsened as BMI increased. Conclusion(s) Success rates in recipient cycles are highest in those with low and normal BMI. Furthermore, there is a progressive and statistically significant worsening of outcomes in groups with higher BMI with respect to clinical pregnancy and live birth rate.

KW - BMI

KW - IVF

KW - Obesity

KW - donor

KW - recipient

KW - success rates

UR - http://www.scopus.com/inward/record.url?scp=84949674062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949674062&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2015.10.015

DO - 10.1016/j.fertnstert.2015.10.015

M3 - Article

C2 - 26523329

AN - SCOPUS:84949674062

SN - 0015-0282

VL - 105

SP - 364

EP - 368

JO - Fertility and sterility

JF - Fertility and sterility

IS - 2

ER -

Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this