TY - JOUR
T1 - Preferential reinnervation of motor nerves by regenerating motor axons
AU - Brushart, T. M.E.
PY - 1988
Y1 - 1988
N2 - Regeneration of axons into inappropriate distal nerve branches may adversely affect functional recovery after peripheral nerve suture. The degree to which motor axons reinnervate sensory nerves, and vice versa, has not been determined. In these experiments, HRP is used to quantify the sensory and motor neurons that reinnervate sensory and motor branches of the rat femoral nerve after proximal severance and repair. Motoneurons preferentially reinnervate the motor branch in juveniles and adults, even if the repair is intentionally misaligned or a gap is imposed between proximal and distal stumps. A specific interaction thus occurs between regenerating motor axons and the Schwann cell tubes that lead to the motor branch. This interaction is independent of mechanical axon alignment.
AB - Regeneration of axons into inappropriate distal nerve branches may adversely affect functional recovery after peripheral nerve suture. The degree to which motor axons reinnervate sensory nerves, and vice versa, has not been determined. In these experiments, HRP is used to quantify the sensory and motor neurons that reinnervate sensory and motor branches of the rat femoral nerve after proximal severance and repair. Motoneurons preferentially reinnervate the motor branch in juveniles and adults, even if the repair is intentionally misaligned or a gap is imposed between proximal and distal stumps. A specific interaction thus occurs between regenerating motor axons and the Schwann cell tubes that lead to the motor branch. This interaction is independent of mechanical axon alignment.
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U2 - 10.1523/jneurosci.08-03-01026.1988
DO - 10.1523/jneurosci.08-03-01026.1988
M3 - Article
C2 - 3346713
AN - SCOPUS:0023835563
SN - 0270-6474
VL - 8
SP - 1026
EP - 1031
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 3
ER -