TY - JOUR
T1 - Prednisone Schedule for Myasthenia Gravis
AU - Mcquillen, Michael P.
AU - Drachman, Daniel B.
AU - Seybold, Marjorie E.
PY - 1974/3/14
Y1 - 1974/3/14
N2 - Te the Editor: Although our experience with gradually increasing doses of prednisone in myasthenia gravis is limited, it differs sufficiently from that of Seybold and Drachman (N Engl J Med 290:81–84, 1974) to warrant comment. Three patients have been treated since June, 1973, with the regimen that they outline. All had moderately severe generalized weakness, including bulbar involvement. All experienced fluctuations in strength from the outset of therapy, with weakness on the days off prednisone. Fluctuations preceded by a week or more any perceptible trend toward improvement, and was such as to make swallowing marginal on the “off” day. In ….
AB - Te the Editor: Although our experience with gradually increasing doses of prednisone in myasthenia gravis is limited, it differs sufficiently from that of Seybold and Drachman (N Engl J Med 290:81–84, 1974) to warrant comment. Three patients have been treated since June, 1973, with the regimen that they outline. All had moderately severe generalized weakness, including bulbar involvement. All experienced fluctuations in strength from the outset of therapy, with weakness on the days off prednisone. Fluctuations preceded by a week or more any perceptible trend toward improvement, and was such as to make swallowing marginal on the “off” day. In ….
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U2 - 10.1056/NEJM197403142901120
DO - 10.1056/NEJM197403142901120
M3 - Letter
C2 - 4812507
AN - SCOPUS:0016391734
SN - 0028-4793
VL - 290
SP - 631
EP - 632
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 11
ER -