Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans

O. M. Wolkowitz; N. M. Papadopoulos; R. Costello; A. Breier; A. R. Doran; D. Pickar; D. Rubinow

doi:10.1016/0306-4530(90)90024-4

Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans

O. M. Wolkowitz, N. M. Papadopoulos, R. Costello, A. Breier, A. R. Doran, D. Pickar, D. Rubinow

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Corticosteroids reportedly decrease blood-brain barrier (BBB) permeability and/or CNS IgG synthesis in patients with multiple sclerosis or brain tumors. However, these effects have not been studied in healthy humans. We investigated the effects of prednisone, 80 mg/day for five days, on the ratio of cerebrospinal fluid (CSF) albumin/serum albumin, a measure of blood-brain barrier (BBB) permeability, and on CSF and serum IgG levels in six healthy, normal volunteers. We found significant steroid-induced decreases in serum and CSF albumin levels and in serum IgG levels. However, we found only a nonsignificant decrease in BBB permeability and no significant change in CNS IgG synthesis. These findings, based on a small number of volunteers, suggest that it may be difficult to further decrease BBB permeability and CNS IgG synthesis in medically healthy subjects.

Original language	English (US)
Pages (from-to)	155-158
Number of pages	4
Journal	Psychoneuroendocrinology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1016/0306-4530(90)90024-4
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Psychiatry and Mental health
Biological Psychiatry
Endocrine and Autonomic Systems
Psychology(all)

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10.1016/0306-4530(90)90024-4

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title = "Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans",

abstract = "Corticosteroids reportedly decrease blood-brain barrier (BBB) permeability and/or CNS IgG synthesis in patients with multiple sclerosis or brain tumors. However, these effects have not been studied in healthy humans. We investigated the effects of prednisone, 80 mg/day for five days, on the ratio of cerebrospinal fluid (CSF) albumin/serum albumin, a measure of blood-brain barrier (BBB) permeability, and on CSF and serum IgG levels in six healthy, normal volunteers. We found significant steroid-induced decreases in serum and CSF albumin levels and in serum IgG levels. However, we found only a nonsignificant decrease in BBB permeability and no significant change in CNS IgG synthesis. These findings, based on a small number of volunteers, suggest that it may be difficult to further decrease BBB permeability and CNS IgG synthesis in medically healthy subjects.",

author = "Wolkowitz, {O. M.} and Papadopoulos, {N. M.} and R. Costello and A. Breier and Doran, {A. R.} and D. Pickar and D. Rubinow",

year = "1990",

doi = "10.1016/0306-4530(90)90024-4",

language = "English (US)",

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T1 - Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans

AU - Wolkowitz, O. M.

AU - Papadopoulos, N. M.

AU - Costello, R.

AU - Breier, A.

AU - Doran, A. R.

AU - Pickar, D.

AU - Rubinow, D.

PY - 1990

Y1 - 1990

N2 - Corticosteroids reportedly decrease blood-brain barrier (BBB) permeability and/or CNS IgG synthesis in patients with multiple sclerosis or brain tumors. However, these effects have not been studied in healthy humans. We investigated the effects of prednisone, 80 mg/day for five days, on the ratio of cerebrospinal fluid (CSF) albumin/serum albumin, a measure of blood-brain barrier (BBB) permeability, and on CSF and serum IgG levels in six healthy, normal volunteers. We found significant steroid-induced decreases in serum and CSF albumin levels and in serum IgG levels. However, we found only a nonsignificant decrease in BBB permeability and no significant change in CNS IgG synthesis. These findings, based on a small number of volunteers, suggest that it may be difficult to further decrease BBB permeability and CNS IgG synthesis in medically healthy subjects.

AB - Corticosteroids reportedly decrease blood-brain barrier (BBB) permeability and/or CNS IgG synthesis in patients with multiple sclerosis or brain tumors. However, these effects have not been studied in healthy humans. We investigated the effects of prednisone, 80 mg/day for five days, on the ratio of cerebrospinal fluid (CSF) albumin/serum albumin, a measure of blood-brain barrier (BBB) permeability, and on CSF and serum IgG levels in six healthy, normal volunteers. We found significant steroid-induced decreases in serum and CSF albumin levels and in serum IgG levels. However, we found only a nonsignificant decrease in BBB permeability and no significant change in CNS IgG synthesis. These findings, based on a small number of volunteers, suggest that it may be difficult to further decrease BBB permeability and CNS IgG synthesis in medically healthy subjects.

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Prednisone effects on blood-brain barrier permeability and CNS IgG synthesis in healthy humans

Abstract

ASJC Scopus subject areas

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