TY - JOUR
T1 - Predictors of fetal growth in maternal HIV disease
AU - Iqbal, Sara N.
AU - Kriebs, Jan
AU - Harman, Christopher
AU - Alger, Lindsay
AU - Kopelman, Jerome
AU - Turan, Ozhan
AU - Gungor, Sadettin
AU - Malinow, Andrew
AU - Baschat, Ahmet Alexander
PY - 2010/7/29
Y1 - 2010/7/29
N2 - We sought to determine predictors of fetal growth restriction in maternal HIV disease. Pregnant HIV-positive women on antiretroviral therapy were monitored with serial viral load and CD4 counts. Individualized growth potential (GP) percentile was calculated for birth weight (BW). BW <10th GP percentile defined fetal growth restriction (FGR). Multiple medical and social factors, CD4 count, viral load, and antiretroviral therapy were tested for impact on fetal growth using chi-square and multiple regression analysis. Two hundred eleven women were studied. CD4 count <200 in the first trimester was strongly associated with FGR (odds ratio 8.75, 95% confidence interval 2.88 to 26.52). Maternal age (p=0.02) and smoking (p=0.03) were independent cofactors for FGR (Nagelkerke r2=0.33). No other factors demonstrated an independent effect. Severity of maternal HIV disease as indicated by the CD4 count, rather than placental exposure to viral load, predicts FGR. Smoking has an independent detrimental effect on fetal growth.
AB - We sought to determine predictors of fetal growth restriction in maternal HIV disease. Pregnant HIV-positive women on antiretroviral therapy were monitored with serial viral load and CD4 counts. Individualized growth potential (GP) percentile was calculated for birth weight (BW). BW <10th GP percentile defined fetal growth restriction (FGR). Multiple medical and social factors, CD4 count, viral load, and antiretroviral therapy were tested for impact on fetal growth using chi-square and multiple regression analysis. Two hundred eleven women were studied. CD4 count <200 in the first trimester was strongly associated with FGR (odds ratio 8.75, 95% confidence interval 2.88 to 26.52). Maternal age (p=0.02) and smoking (p=0.03) were independent cofactors for FGR (Nagelkerke r2=0.33). No other factors demonstrated an independent effect. Severity of maternal HIV disease as indicated by the CD4 count, rather than placental exposure to viral load, predicts FGR. Smoking has an independent detrimental effect on fetal growth.
KW - CD4 lymphocyte count
KW - Fetal growth restriction
KW - HIV
KW - pregnancy
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U2 - 10.1055/s-0030-1248937
DO - 10.1055/s-0030-1248937
M3 - Article
C2 - 20200807
AN - SCOPUS:77954879009
SN - 0735-1631
VL - 27
SP - 517
EP - 523
JO - American journal of perinatology
JF - American journal of perinatology
IS - 7
ER -