@inproceedings{49db41bf51f1413789502429f31d92b2,
title = "Prediction of protein-protein interactions using alpha shape modeling",
abstract = "Protein-protein interactions play important roles in a lot of biological progress. Previous studies about protein-protein interactions were mainly based on sequence analysis. As more 3D structural information can be obtained from protein-protein complexes, structural analysis becomes feasible and useful. In this study, we used structural alignment to predict the protein-binding site and apply 3D alpha shape modeling to analyze the interface characteristics. We have developed a method for protein-protein interaction prediction. The result indicates good performance of our method in discriminating protein-binding structures from non-protein binding structures. Our method outperforms the previous methods based on the Matthews correlation coefficient.",
keywords = "Alpha shape, Protein-protein interaction, Structural alignment",
author = "Weiqiang Zhou and Hong Yan and Xiaodan Fan and Quan Hao",
year = "2011",
month = jul,
day = "13",
doi = "10.1063/1.3596648",
language = "English (US)",
isbn = "9780735409316",
series = "AIP Conference Proceedings",
pages = "244--252",
booktitle = "2011 International Symposium on Computational Models for Life Sciences, CMLS-11",
note = "2011 International Symposium on Computational Models for Life Sciences, CMLS-11 ; Conference date: 11-10-2011 Through 13-10-2011",
}