Predicting the spatial dynamics of rabies epidemics on heterogeneous landscapes

David L. Smith, Brendan Lucey, Lance A. Waller, James E. Childs, Leslie A. Real

Research output: Contribution to journalArticlepeer-review

255 Scopus citations


Often as an epidemic spreads, the leading front is irregular, reflecting spatial variation in local transmission rates. We developed a methodology for quantifying spatial variation in rates of disease spread across heterogeneous landscapes. Based on data for epidemic raccoon rabies in Connecticut, we developed a stochastic spatial model of rabies spread through the state's 169 townships. We quantified spatial variation in transmission rates associated with human demography and key habitat features. We found that large rivers act as semipermeable barriers, leading to a 7-fold reduction in the local rates of propagation. By combining the spatial distribution of major rivers with long-distance dispersal we were able to account for the observed irregular pattern of disease spread across the state without recourse to direct assessment of host-pathogen populations.

Original languageEnglish (US)
Pages (from-to)3668-3672
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number6
StatePublished - Mar 19 2002
Externally publishedYes

ASJC Scopus subject areas

  • General


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