Predicting the dependence liability of stimulant drugs

R. R. Griffiths, J. V. Brady, G. E. Bigelow

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This paper reviews animal drug self-administration methods and describes their usefulness in providing information about the dependence liability of psychomotor stimulant drugs. Specifically, animal self-administration results with a wide range of psychomotor stimulants is reviewed, and approaches for measuring the relative reinforcing efficacy of different drugs in animals are described. Another section considers the relationship between the reinforcing and anorectic properties of appetite suppressant drugs. The correspondence of the animal drug self-aministration results to clinical information relevant to human drug abuse is also discussed.

Original languageEnglish (US)
Pages (from-to)182-196
Number of pages15
JournalNIDA Research Monograph Series
VolumeNo. 37
StatePublished - 1981

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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