@article{b756ae44fba942f49566bdb01431d491,
title = "Predicting and optimizing the territory of blood-brain barrier opening by superselective intra-arterial cerebral infusion under dynamic susceptibility contrast MRI guidance",
abstract = "Interventional neuroradiology techniques are minimally invasive and allow for superselective drug delivery to specific brain regions. The passage of most agents, however, is impaired by the blood-brain barrier (BBB). Despite its discovery over 40 years ago, hyperosmotic BBB opening (BBBO) remains highly variable, preventing its widespread implementation. Here, we report on a technique that enables the prediction and optimization of the BBBO territory. We found that the microcatheter tip position and the speed of hyperosmolar mannitol injection, both major determinants of the targeted territory, can be modulated in real-time as guided by trans-catheter perfusion MRI.",
keywords = "Blood-brain barrier opening, MRI, intra-arterial, mannitol",
author = "Miroslaw Janowski and Piotr Walczak and Pearl, {Monica S.}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Sheik Zayed Institute for Pediatric Surgical Innovation, Children{\textquoteright}s National Medical Center, Children{\textquoteright}s Research Institute, Washington, DC and the Scholar Award in Neuroradiology Research, The Foundation of the American Society of Neuroradiology (MP). MSCRFII-0193, MSCRFII- 0052, MSCRFE-0178, 2RO1 NS076573 and National Centre for Research and Development grant No 101 in ERA-NET NEURON project: {\textquoteleft}{\textquoteleft}MEMS-IRBI{\textquoteright}{\textquoteright}. MJ was supported by a Kolumb Fellowship from the Foundation for Polish Science. Publisher Copyright: {\textcopyright} The Author(s) 2015.",
year = "2016",
month = mar,
day = "1",
doi = "10.1177/0271678X15615875",
language = "English (US)",
volume = "36",
pages = "569--575",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "3",
}