Prediabetic obese adolescents have a more atherogenic lipoprotein profile compared with normoglycemic obese peers

Sheela N. Magge, Divya Prasad, Dorit Koren, Paul R. Gallagher, Emile R. Mohler, Nicolas Stettler, Lorraine E. Levitt Katz, Daniel J. Rader

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: To compare lipoprotein profiles of prediabetic to normoglycemic obese adolescents. Study design: Cross-sectional study of 95 obese, pubertal adolescents (12-17 years), who underwent oral glucose tolerance test, lipid panel, and lipoprotein subclass particle analysis (nuclear magnetic resonance spectroscopy). Univariate and linear regression analyses compared prediabetic and normoglycemic groups. Results: Of 95 obese adolescents enrolled in the study, 22.1% (n = 21) had prediabetes. They were similar to normoglycemic adolescents (n = 74) in age, race, body mass index, standard lipids, total low-density lipoprotein particles (LDL-P), and total high-density lipoprotein particles (HDL-P). However, prediabetics had higher concentrations of small LDL-P (714.0 ± 288.0 vs 537.7 ± 266.5 nmol/L, P = .01) and smaller LDL-P size (20.73 ± 0.41 vs 21.18 ± 0.65 nm, P = .003), than normoglycemic youth. Prediabetics had higher small HDL-P (18.5 ± 3.8 vs 16.6 ± 3.9 umol/L, P = .046), lower large HDL-P (4.49 ± 2.0 vs 6.32 ± 2.6 umol/L, P = .004), and smaller HDL-P size (8.73 ± 0.31 vs 9.01 ± 0.39 nm, P = .003). After adjusting for demographics, Tanner stage, and body mass index using multiple linear regression, all differences remained significant except for small HDL-P. After additional adjustment for Homeostasis Model Assessment-Insulin Resistance Index, only LDL-P size difference remained significant. Conclusion: Obese prediabetic adolescents have a significantly more atherogenic lipoprotein profile compared with obese normoglycemic peers. Prediabetic adolescents may benefit from more aggressive interventions to decrease future cardiovascular risk.

Original languageEnglish (US)
Pages (from-to)881-886
Number of pages6
JournalJournal of Pediatrics
Issue number5
StatePublished - Nov 2012
Externally publishedYes


  • BMI
  • Body mass index
  • CHOP
  • CVD
  • Cardiovascular disease
  • HDL-C
  • HDL-P
  • High-density lipoprotein cholesterol
  • High-density lipoprotein particles
  • Homeostasis Model Assessment-Insulin Resistance Index
  • IFG
  • IGT
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • LDL-C
  • LDL-P
  • Low-density lipoprotein cholesterol
  • Low-density lipoprotein particles
  • NMR
  • Nuclear magnetic resonance
  • The Children's Hospital of Philadelphia
  • VLDL-P
  • Very-low-density lipoprotein particles

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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